Pharmacodynamic interactions of cypermethrin and centrally acting drugs in mice.

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dc.contributor.authorVarshneya, Cen_US
dc.contributor.authorKanwar, R Sen_US
dc.date.accessioned1995-04-01en_US
dc.date.accessioned2009-06-01T07:31:10Z
dc.date.available1995-04-01en_US
dc.date.available2009-06-01T07:31:10Z
dc.date.issued1995-04-01en_US
dc.description.abstractCypermethrin a widely used insecticide of Pyrethroids (type II) group, was administered in mice at two dose levels (1/10 of LD50 i.e. 2.5 mg/kg and 1/5 of LD50 i.e. 5.0 mg/kg) and pharmacodynamic interactions of insecticide were studied with centrally acting drugs viz. pentobarbital sodium, amphetamine, pentylenetetrazole, acepromazine and analgin. Cypermethrin pretreatment potentiated the actions of pentobarbital and pentylene-tetrazole as evidenced by an increase in pentobarbital induced hypnosis and duration of pentylene-tetrazole induced chemoshock seizures. Tranquilizing action of acepromazine was potentiated but there was decrease in amphetamine influenced locomotor activity at both the dose levels. Cypermethrin pretreatment, however, did not have any pharmacodynamic interaction with analgin.en_US
dc.description.affiliationDepartment of Pharmacology and Toxicology, College of Veterinary and Animal Science, Palampur.en_US
dc.identifier.citationVarshneya C, Kanwar RS. Pharmacodynamic interactions of cypermethrin and centrally acting drugs in mice. Indian Journal of Physiology and Pharmacology. 1995 Apr; 39(2): 154-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108216
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcepromazine --pharmacologyen_US
dc.subject.meshAmphetamine --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCentral Nervous System Agents --pharmacologyen_US
dc.subject.meshDipyrone --pharmacologyen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshInsecticides --toxicityen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMotor Activity --drug effectsen_US
dc.subject.meshPentobarbital --pharmacologyen_US
dc.subject.meshPentylenetetrazole --pharmacologyen_US
dc.subject.meshPyrethrins --toxicityen_US
dc.subject.meshSeizures --chemically induceden_US
dc.subject.meshSleep --drug effectsen_US
dc.titlePharmacodynamic interactions of cypermethrin and centrally acting drugs in mice.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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