Red cell distribution width as a diagnostic marker in neonatal sepsis

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dc.contributor.authorDeka, Anupamaen_US
dc.contributor.authorP., Aravinden_US
dc.date.accessioned2020-09-24T07:47:45Z
dc.date.available2020-09-24T07:47:45Z
dc.date.issued2020-04
dc.description.abstractBackground: The early diagnosis of neonatal sepsis, a significant cause of neonatal morbidity and mortality still remains a challenge. Red-cell Distribution Width (RDW) vary significantly in conditions associated with inflammation and infection like sepsis. The study aims to find the normal range of RDW in healthy newborns and investigate the role of RDW in the early diagnosis of neonatal sepsis.Methods: This is a prospective observational study, 50 normal and 50 sepsis neonates were considered for the study. The neonatal sepsis group consisted of neonates with (i) Positive sepsis screen with/without clinical features of neonatal sepsis and/or (ii) Blood, urine or CSF culture positive or signs of pneumonia on chest x-ray. The mean RDW and the relationship between RDW and neonatal sepsis were analysed using appropriate statistical methods in SPSS-25 software.Results: Mean RDW (%) was significantly higher in sepsis neonates (18.59'1.28) than in normal newborns (16.21'1.35). RDW had statistical significance with CRP (C-Reactive Protein) in the sepsis group. RDW had significant relationship with the diagnosis of neonatal sepsis with a p value of 0.000. An RDW cut-off level of 17.25% had 86% sensitivity, 87% specificity, and 93.5% accuracy in diagnosing neonatal sepsis.Conclusions: RDW helps as a diagnostic test in the early diagnosis of neonatal sepsis.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Silchar Medical College and Hospital, Assam, Indiaen_US
dc.identifier.citationDeka Anupama, P. Aravind. Red cell distribution width as a diagnostic marker in neonatal sepsis. International Journal of Contemporary Pediatrics. 2020 Apr; 7(4): 820-825en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204531
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20201137en_US
dc.subjectC-Reactive Proteinen_US
dc.subjectNeonatal sepsisen_US
dc.subjectPneumoniaen_US
dc.subjectRed-cell distribution widthen_US
dc.subjectSepsis screenen_US
dc.titleRed cell distribution width as a diagnostic marker in neonatal sepsisen_US
dc.typeJournal Articleen_US
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