Therapy of acanthamoeba keratitis--an experimental study.

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dc.contributor.authorPanda, Aen_US
dc.contributor.authorDas, G Ken_US
dc.contributor.authorBiswas, N Ren_US
dc.contributor.authorMittal, Den_US
dc.contributor.authorMohanty, Sen_US
dc.date.accessioned2000-07-15en_US
dc.date.accessioned2009-06-01T06:04:11Z
dc.date.available2000-07-15en_US
dc.date.available2009-06-01T06:04:11Z
dc.date.issued2000-07-15en_US
dc.description.abstractThe study was conducted to determine the efficacy of various drugs/agents in the treatment of experimentally induced Acanthamoeba Keratitis (A. keratitis). Thirty rabbits were divided into 5 equal treatment groups and polyhexamethylene biguanide (PHMB) 0.02%, fluconazole 0.2%, povidone iodine 5%, aprotinin 40 IU/ml and normal saline were administered in a double blind manner, at a dose of one drop, 5 times/day. Neomycin 1700 U/ml was used as a common drug in all groups, with same frequency. Post therapy subsidence of lid oedema, mucopurulent discharge, conjunctival congestion, corneal epithelial defect and anterior chamber reactions were noted. Average healing time in days (Mean +/- S.D.) were 13.67 +/- 1.21, 22 +/- 1.41, 23.5 +/- 1.05, 17.0 +/- 1.41 and 28.0 +/- 1.90 for PHMB, fluconazole, povidone iodine, aprotinin and normal saline respectively. Lid oedema, mucopurulent discharge and conjunctival congestion improved faster in PHMB and aprotinin treated eyes. The results of this study suggest that PHMB is a better drug for A. keratitis, while aprotinin may be used as an adjuvant drug in the management of A. keratitis.en_US
dc.description.affiliationDr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.en_US
dc.identifier.citationPanda A, Das GK, Biswas NR, Mittal D, Mohanty S. Therapy of acanthamoeba keratitis--an experimental study. Indian Journal of Physiology and Pharmacology. 2000 Jul; 44(3): 363-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107100
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcanthamoeba Keratitis --drug therapyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiguanides --therapeutic useen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluconazole --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshNeomycin --therapeutic useen_US
dc.subject.meshPovidone-Iodine --therapeutic useen_US
dc.subject.meshRabbitsen_US
dc.titleTherapy of acanthamoeba keratitis--an experimental study.en_US
dc.typeJournal Articleen_US
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