Seroprevalence of tetanus antibody in the Thai population: a national survey.

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dc.contributor.authorChatchatee, Pantipaen_US
dc.contributor.authorChatproedprai, Susheeraen_US
dc.contributor.authorWarinsathien, Porpiten_US
dc.contributor.authorTharmaphornpilas, Piyaniten_US
dc.contributor.authorYoocharoen, Pornsaken_US
dc.contributor.authorWarintrawat, Sirisaken_US
dc.contributor.authorTheamboonlers, Apiradeeen_US
dc.contributor.authorChongsrisawat, Voranushen_US
dc.contributor.authorPoovorawan, Yongen_US
dc.date.accessioned2009-05-27T17:06:57Z
dc.date.available2009-05-27T17:06:57Z
dc.date.issued2007-12-12en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractTetanus is a disease with high mortality and the most important measure for effective prevention is vaccination. Tetanus immunization has been introduced to Thailand's national immunization program for 30 years. Yet, the coverage and seroprevalence of tetanus antibody in vast parts of the population has not been assessed. This study has been performed on 1,277 subjects aged between 6 months and 60 years or above from four geographically distinct provinces of Thailand. Tetanus antibody levels were measured using a commercially available ELISA kit. Most of the Thai population had immunity against tetanus. The level of antibodies to tetanus, as demonstrated by the geometric mean titer of antibody (GMT) (and 95% confidence interval) was 2.62 (2.34-2.91) IU/ml. The highest and lowest GMT was found in subjects aged between 5 and 9 years, and above 60 years of age with GMT (and 95% confidence intervals) of 3.64 (3.34-3.96) and 1.24 (0.67-2.29) IU/ml respectively. The minimum protective level of antitoxin (>0.01 IU/ml) was detected in 99.7 % of subjects. More than 90% of subjects displayed durable antibody protection levels (DAPL) (> or = 1.0 IU/ml), except for subjects above the age of 60 years (82%). According to this study, the majority of the population expresses tetanus antibody levels that can confer long term protection. Yet, considering the lowest GMT and the highest incidence of tetanus cases found in subjects aged above 60 years, re-immunization should be targeted at this age group especially if they had sustained any tetanus-prone injury.en_US
dc.description.affiliationCenter of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Patumwan, Bangkok 10330, Thailand.en_US
dc.identifier.citationChatchatee P, Chatproedprai S, Warinsathien P, Tharmaphornpilas P, Yoocharoen P, Warintrawat S, Theamboonlers A, Chongsrisawat V, Poovorawan Y. Seroprevalence of tetanus antibody in the Thai population: a national survey. Asian Pacific Journal of Allergy and Immunology. 2007 Dec; 25(4): 219-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36484
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAntibodies, Bacterial --blooden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshData Collectionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunizationen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.subject.meshTetanus --blooden_US
dc.subject.meshThailanden_US
dc.titleSeroprevalence of tetanus antibody in the Thai population: a national survey.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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