Association between p53 codon 72 and GSTM1 polymorphisms and risk of hepatocellular carcinoma

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dc.contributor.authorDanai Tiwawechen_US
dc.contributor.authorWutthi Sumetchotimaythaen_US
dc.contributor.authorAree Prastthipayongen_US
dc.contributor.authorYaninee Jarratwisarutpornen_US
dc.contributor.authorPatcharin Homchaemen_US
dc.contributor.authorTakafumi Ishidaen_US
dc.date.accessioned2011-02-22T08:15:48Z
dc.date.available2011-02-22T08:15:48Z
dc.date.created2010-04-07en_US
dc.date.issued2010-04-07en_US
dc.description.abstractHepatocellular carcinoma (HCC) is a serious public health problem that caused vastly losses in Thailand annually. Recently, P53 codon 72 and GSTM1 polymorphisms have been found to associate with several cancers. The aim of this study is to investigate the association between P53 codon 72 and GSTM1 polymorphisms and risk of HCC development in Thais. The frequencies of P53 codon 72 genotypes (Arg/Arg, Arg/Pro and Pro/Pro genotypes) and GSTM1 genotypes (GSTM1+) and (GSTM1-) from 200 cases of HCC as well as 400 age-matched healthy control were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR, respectively. In overall, the frequencies of P53 codon 72 polymorphism in HCC group were significantly different from those of healthy control. The Pro/Pro carriers had increased risk for HCC at 1.9-fold as compared to Arg/Arg carriers (OR=1.9; 95%CI=1.2-3.3). Similarly, the overall of frequencies of GSTM1 genotypes of GSTM1 polymorphism in HCC group were significantly different from those of healthy control. In addition, GSTM1- carriers had increased risk for HCC at 1.8-fold as compared to GSTM1+ carriers (OR=1.8; 95%CI=1.3-2.5). The results of this study suggest that P53 codon 72 and GSTM1 polymorphisms are associated with the increased risk of HCC and may be a useful tool for predicting and searching the high risk group of HCC in Thai population.en_US
dc.identifier.citationThai Cancer Journal; Vol.29 No.1 January-March 2009; 25-34en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/132354
dc.language.isoen_USen_US
dc.publisherThai Cancer Journalen_US
dc.rightsNational Cancer Institute of Thailand, Bangkok, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TCJ/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TCJ/article/view/3059en_US
dc.titleAssociation between p53 codon 72 and GSTM1 polymorphisms and risk of hepatocellular carcinomaen_US
dc.typeResearch Articlesen_US
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