Vitamin D deficiency in patients with tuberculosis and its correlation with glycemic status

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dc.contributor.authorKaroli, Rituen_US
dc.contributor.authorShakya, Shobhiten_US
dc.contributor.authorSingh, Prem Shankeren_US
dc.date.accessioned2020-11-18T10:00:37Z
dc.date.available2020-11-18T10:00:37Z
dc.date.issued2020-01
dc.description.abstractBackground: Comorbidity of diabetes and tuberculosis has serious health implications. Presence of diabetes at least three times increases the risk of tuberculosis which may be mediated by an abnormal innate immune response due to hyperglycaemia or low vitamin D levels.Aim of the study- Present study was carried out to investigate whether lower serum 25(OH) D might be associated with higher prevalence of pulmonary or extra pulmonary tuberculosis which might provide an evidence for a role of vitamin D in the comorbidity of these two diseases and does it have any correlation with glycemic status.Methods: In a hospital based cross sectional study, 264 patients with newly diagnosed tuberculosis were enrolled and according to glycemic status they were divided into three groups. They were assessed for vitamin D deficiency in addition to routine laboratory and biochemical parameters.Results: The patients with diabetes had significantly lower vitamin D levels. The prevalence of severe vitamin D deficiency was highest in patients who had diabetes with tuberculosis. There was negative correlation between vitamin D levels and Hba1C and extensiveness of pulmonary tuberculosisConclusions: Serum vitamin D levels were significantly lower in tuberculosis patients with pre-diabetes and type 2 diabetes compared with those, who had normal glycemic status. We suggest that there is a need to pay more attention to vitamin D status in this country and if there is coexisting diabetes or impaired glucose intolerance, emphasis on vitamin D supplementation can be of utmost importance.en_US
dc.identifier.affiliationsDepartment of Medicine, Dr. RML Institute of Medical Sciences, Gomti Nagar, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationKaroli Ritu, Shakya Shobhit, Singh Prem Shanker. Vitamin D deficiency in patients with tuberculosis and its correlation with glycemic status. International Journal of Research in Medical Sciences. 2020 Jan; 8(1): 239-243en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212032
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20195915en_US
dc.subjectDiabetes mellitusen_US
dc.subjectTuberculosisen_US
dc.subjectVitamin Den_US
dc.titleVitamin D deficiency in patients with tuberculosis and its correlation with glycemic statusen_US
dc.typeJournal Articleen_US
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