Screening for the carriers of thalassemias and abnormal hemoglobins at the community level.

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dc.contributor.authorWinichagoon, Pen_US
dc.contributor.authorThitivichianlert, Aen_US
dc.contributor.authorLebnak, Ten_US
dc.contributor.authorPiankijagum, Aen_US
dc.contributor.authorFucharoen, Sen_US
dc.date.accessioned2009-05-27T15:17:35Z
dc.date.available2009-05-27T15:17:35Z
dc.date.issued2002-12-21en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThalassemia and abnormal hemoglobins are common genetic disorders in Southeast Asia. Thalassemia is not only an important public health problem but also a socio-economic problem of many countries in the region. The approach to deal with the thalassemic problem is to prevent and control births of the new cases. This requires an accurate identification of couple at high risk to have a thalassemic child. The diagnosis of thalassemia carriers need several tests that are not practical for screening the population at large. In this study we used two simple laboratory tests to screen for potential thalassemia carriers and hemoglobin E individuals. Three-hundred pregnant women and 40 spouses were recruited in this study. The methods were the red cell osmotic fragility (OF) screening test with 0.36% NaCl and the dichlorophenolindophenol (DCIP) precipitation test to detect Hb E and unstable hemoglobins. Standard methods for red cell indices, hemoglobin analysis and detection of alpha-thalassemia by immunological method were also performed to confirm genotypes of thalassemia. The results showed that 98 women (32.7%) were carriers of thalassemias and hemoglobin E. The number of false positive by OF test was 3.2% and by DCIP test was 0.6%. Sensitivity and specificity of OF test were 89.5% and 93.3%, respectively whereas those of DCIP test were 100%. Of the 40 couples investigated, one was found to be at risk of having beta-thalassemia/Hb E fetus. Screening techniques including one tube osmotic fragility and DCIP precipitation tests are sensitive and specific for the detection of thalassemia and unstable hemoglobins such as Hb E. The techniques are also simple, economic, rapid, and give minimal false negative result.en_US
dc.description.affiliationThalassemia Research Center, Institute of Science and Technology for Research and Development, Mahidol University, Thailand.en_US
dc.identifier.citationWinichagoon P, Thitivichianlert A, Lebnak T, Piankijagum A, Fucharoen S. Screening for the carriers of thalassemias and abnormal hemoglobins at the community level. The Southeast Asian Journal of Tropical Medicine and Public Health. 2002 ; 33 Suppl 2(): 145-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32414
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshCarrier Stateen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobinopathies --diagnosisen_US
dc.subject.meshHemoglobins, Abnormal --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screening --methodsen_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshReproducibility of Resultsen_US
dc.subject.meshThalassemia --diagnosisen_US
dc.titleScreening for the carriers of thalassemias and abnormal hemoglobins at the community level.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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