Lung cancer in the older population: Interactive effects of angiotensin converting enzyme gene polymorphism (rs 4340 ID) and tobacco addiction in risk assessment

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dc.contributor.authorBanerjee, Joyitaen_US
dc.contributor.authorGupta, Abhisheken_US
dc.contributor.authorAgnihotri, Verticaen_US
dc.contributor.authorPradhan, Rashmitaen_US
dc.contributor.authorKandel, Rameshen_US
dc.contributor.authorUpadhyay, Ashish Den_US
dc.contributor.authorDwivedi, Sadananden_US
dc.contributor.authorKumar, Laliten_US
dc.contributor.authorDey, Sharmisthaen_US
dc.contributor.authorAparajit, B Deyen_US
dc.date.accessioned2023-08-09T06:04:26Z
dc.date.available2023-08-09T06:04:26Z
dc.date.issued2023-03
dc.description.abstractBackground: rs4340ID polymorphism of angiotensin-converting enzyme (ACE) correlates with serum ACE levels in many known cancers. This study analyzed ACE rs4340 ID polymorphism in lung cancer (LC) in older patients of North India and correlated it with addiction status. Methods: The study enrolled all subjects aged 60 years and above with 154 LC and 205 healthy controls. Genotyping was done by polymerase chain reaction (PCR) and validated by sequencing of 10% of the sample. Statistical analysis was done by SPSS Statistics 21. Results: Genotype II was observed to have a significant 2.21-fold increased risk of LC as compared to the DD genotype and 3.43-folds enhanced risk with interaction of I allele with tobacco consumption habits as compared to D allele in LC was seen. Conclusion: The risk of LC was higher with II genotype as compared to DD genotype. Interactive effect showed that I allele with tobacco habits may increase the risk of LC.en_US
dc.identifier.affiliationsDepartments of Geriatric Medicineen_US
dc.identifier.affiliationsBiophysicsen_US
dc.identifier.affiliationsBiostatistics anden_US
dc.identifier.affiliationsMedical Oncology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationBanerjee Joyita, Gupta Abhishek, Agnihotri Vertica, Pradhan Rashmita, Kandel Ramesh, Upadhyay Ashish D, Dwivedi Sadanand, Kumar Lalit, Dey Sharmistha, Aparajit B Dey. Lung cancer in the older population: Interactive effects of angiotensin converting enzyme gene polymorphism (rs 4340 ID) and tobacco addiction in risk assessment. Indian Journal of Cancer . 2023 Mar; 60(1): 12-17en_US
dc.identifier.issn0019-509X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221747
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.4103/ijc.IJC_1082_19en_US
dc.subjectAngiotensin converting enzymeen_US
dc.subjectelderlyen_US
dc.subjectlung canceren_US
dc.subjectpolymorphismen_US
dc.subjecttobaccoen_US
dc.titleLung cancer in the older population: Interactive effects of angiotensin converting enzyme gene polymorphism (rs 4340 ID) and tobacco addiction in risk assessmenten_US
dc.typeJournal Articleen_US
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