Rapid prenatal karyotyping using foetal blood obtained by cordocentesis.

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dc.contributor.authorMathur, Rolien_US
dc.contributor.authorDubey, Sudhishaen_US
dc.contributor.authorHamilton, Shireenen_US
dc.contributor.authorSingh, Geetaen_US
dc.contributor.authorDeka, Deepikaen_US
dc.contributor.authorKriplani, Alkaen_US
dc.contributor.authorKabra, Madhulikaen_US
dc.contributor.authorMenon, P S Nen_US
dc.date.accessioned2002-03-05en_US
dc.date.accessioned2009-06-03T05:25:12Z
dc.date.available2002-03-05en_US
dc.date.available2009-06-03T05:25:12Z
dc.date.issued2002-03-05en_US
dc.description.abstractBACKGROUND: Prenatal karyotyping using foetal blood samples obtained by cordocentesis is a useful method of detecting abnormal chromosomes in the foetus. METHODS: Cordocentesis was performed in 187 cases for prenatal karyotyping between January 1995 and September 2000. Pregnant women were between 18 and 38 weeks of gestation and their ages ranged from 18 to 40 years. The common indications were ultrasonographic abnormalities (47.6%), history of previous Down syndrome (13.3%), advanced maternal age (11.7%), low maternal serum alpha foetoprotein levels (10.7%), previous child with malformation (10.7%), previous child with trisomy (chromosome 13/18) (2.6%), parent a balanced translocation carrier (1.6%) and high maternal serum alpha foetoprotein levels (1.6%). RESULTS: Analysis of 137 successful cultures showed 8 (5.2%) karyotype abnormalities. The remaining samples could not be reported due to the presence of maternal contamination of the sample (12.3%), inadequate sample (6.4%) or culture failure (9.8%). In those with an abnormal karyotype, obstetric management could be altered appropriately. CONCLUSION: In foetuses at high risk of a chromosomal aberration, a rapidly obtained karyotype is helpful in obstetric management.en_US
dc.description.affiliationDepartment of Paediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.en_US
dc.identifier.citationMathur R, Dubey S, Hamilton S, Singh G, Deka D, Kriplani A, Kabra M, Menon PS. Rapid prenatal karyotyping using foetal blood obtained by cordocentesis. National Medical Journal of India. 2002 Mar-Apr; 15(2): 75-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/118355
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdulten_US
dc.subject.meshChromosome Aberrations --embryologyen_US
dc.subject.meshCordocentesisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.titleRapid prenatal karyotyping using foetal blood obtained by cordocentesis.en_US
dc.typeJournal Articleen_US
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