Tri-iodothyronine alters superoxide dismutase expression in a teleost Anabas testudineus.

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dc.contributor.authorSreejith, Pen_US
dc.contributor.authorOommen, O Ven_US
dc.date.accessioned2008-12-26en_US
dc.date.accessioned2009-05-27T09:15:46Z
dc.date.available2008-12-26en_US
dc.date.available2009-05-27T09:15:46Z
dc.date.issued2008-12-26en_US
dc.description.abstractThe effect of tri-iodothyronine (T3) on superoxide dismutase (SOD) expression was evaluated in a teleost Anabas testudineus (cuthyroid fish) by native gel eletrophoresis and Western blot analysis. SOD is an essential enzyme for the survival of oxygen-utilizing organisms. Its expression is altered by the stress, presumably due to the increase in concentration of superoxide radical in cells. Variations of thyroid honnone levels are the major physiological modulators of cellular oxidative stress. T3 administration generates an oxidative stress, which to some extent is neutralized by the changed activity of enzymes like SOD. T3 treatment decreased CuZn SOD density in liver and brain of A. testudineus. The activity of CuZn SOD in liver and brain was confirmed by native gel analysis. The different physiological states of thyroid influenced the CuZn SOD activity. Western blot analysis further confirmed that liver and brain CuZn SOD decreased after T3 treatment. From these findings, it was clear that T3 treatment in euthyroid fish created an oxidative stress condition and thyroid hormone effectively maintained antioxidant status to overcome this situation in teleosts.en_US
dc.description.affiliationDepartment of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram-695 581, Kerala, India.en_US
dc.identifier.citationSreejith P, Oommen OV. Tri-iodothyronine alters superoxide dismutase expression in a teleost Anabas testudineus. Indian Journal of Biochemistry & Biophysics. 2008 Dec; 45(6): 393-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26967
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEnzyme Activation --drug effectsen_US
dc.subject.meshGene Expression Regulation, Enzymologicen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshPerciformes --metabolismen_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.subject.meshSuperoxides --metabolismen_US
dc.subject.meshTriiodothyronine --pharmacologyen_US
dc.titleTri-iodothyronine alters superoxide dismutase expression in a teleost Anabas testudineus.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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