Social harms in injecting drug users participating in the first phase III HIV vaccine trial in Thailand.

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dc.contributor.authorPitisuttithum, Punneeen_US
dc.contributor.authorChoopanya, Kachiten_US
dc.contributor.authorBussaratid, Valaien_US
dc.contributor.authorVanichseni, Suphaken_US
dc.contributor.authorvan Griensven, Fritsen_US
dc.contributor.authorPhonrat, Benjalucken_US
dc.contributor.authorMartin, Michaelen_US
dc.contributor.authorVimutsunthorn, Eiamen_US
dc.contributor.authorSangkum, Udomsaken_US
dc.contributor.authorKitayaporn, Dwipen_US
dc.contributor.authorTappero, Jordan Wen_US
dc.contributor.authorHeyward, Williamen_US
dc.contributor.authorFrancis, Donalden_US
dc.date.accessioned2009-05-27T19:29:08Z
dc.date.available2009-05-27T19:29:08Z
dc.date.issued2007-11-10en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To study related social harms due to identification with a group of participants in an HIV-1 vaccine trial who are potentially high risk for HIV/AIDS. MATERIAL AND METHOD: Two thousand five hundred forty six injecting drug users (IDU) were enrolled in a 36-month vaccine trial. Volunteers received education and risk reduction counseling at every six-month study visit. Social harms were not actively solicited, but volunteers were encouraged to report any during the process of counseling at every six-month visit. If a social harm was reported, a questionnaire was administered and the harm was tracked If necessary, clinic staff assisted in resolving the social harm. RESULTS: Thirty-nine social harms were reported by 37 participants; 33 (84.6%) were disturbances in personal relationships, three (7.7%) in employment, one (2.6%) was medically related, one (2.6%) was related to admission in the military and one (2.6%) was related with misbelieve about the vaccine. The most common reason for disturbances in personal relationships was suspicion of HIV infection (n=20). The impact of these harms on quality of life was characterized as minimal by 31 (79.5%) participants, as moderate by seven (17.9%), and as major by one (2.6%). All social harms were documented to be resolved by the end of the study. CONCLUSION: A few participants reported study-related social harms during the course of the trial. Most harm had minimal impact and all could be resolved by the end of the present study.en_US
dc.description.affiliationVaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. tmppt@mahidol.ac.then_US
dc.identifier.citationPitisuttithum P, Choopanya K, Bussaratid V, Vanichseni S, van Griensven F, Phonrat B, Martin M, Vimutsunthorn E, Sangkum U, Kitayaporn D, Tappero JW, Heyward W, Francis D. Social harms in injecting drug users participating in the first phase III HIV vaccine trial in Thailand. Journal of the Medical Association of Thailand. 2007 Nov; 90(11): 2442-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41218
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAIDS Vaccinesen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --etiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intravenous --adverse effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrejudiceen_US
dc.subject.meshPsychological Testsen_US
dc.subject.meshPsychometricsen_US
dc.subject.meshQuality of Lifeen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshRisk Reduction Behavioren_US
dc.subject.meshRisk-Takingen_US
dc.subject.meshSocial Adjustmenten_US
dc.subject.meshSocial Isolationen_US
dc.subject.meshSocial Perceptionen_US
dc.subject.meshStreet Drugs --adverse effectsen_US
dc.subject.meshSubstance-Related Disorders --psychologyen_US
dc.subject.meshThailanden_US
dc.titleSocial harms in injecting drug users participating in the first phase III HIV vaccine trial in Thailand.en_US
dc.typeClinical Trialen_US
dc.typeClinical Trial, Phase IIIen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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