Antibody testing in Indian children with celiac disease.

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dc.contributor.authorYachha, Surender Kumaren_US
dc.contributor.authorAggarwal, Rakeshen_US
dc.contributor.authorSrinivas, Sen_US
dc.contributor.authorSrivastava, Anshuen_US
dc.contributor.authorSomani, Sanjay Ken_US
dc.contributor.authorItha, Srivenuen_US
dc.date.accessioned2006-05-01en_US
dc.date.accessioned2009-05-29T02:04:00Z
dc.date.available2006-05-01en_US
dc.date.available2009-05-29T02:04:00Z
dc.date.issued2006-05-01en_US
dc.description.abstractBACKGROUND: We prospectively evaluated the usefulness of IgA tissue transglutaminase antibodies (IgA tTG) in the initial diagnosis of celiac disease (CD) and compared its diagnostic potential with that of IgA anti-endomysial antibodies (IgA EMA) and anti-IgA and IgG gliadin antibodies (AGA and AGG, respectively). METHODS: Sera of 23 untreated children fulfilling the revised ESPGHAN criteria for diagnosis of CD (Group I; mean age 10.8 y); 19 disease controls (Group II; mean age 8.5 y) presenting with chronic diarrhea, short stature or both; and 22 healthy children (Group III; mean age 8.8 y) were studied. These were tested in a blinded manner for AGA, AGG, IgA tTG (guinea pig as antigen) and IgA EMA. RESULTS: In Group I, IgA EMA was positive in 19, IgA tTG in 17, AGA in 14 and AGG in 17 patients. In Group II, these tests were positive in 1, 0, 2 and 14 patients, respectively and in Group III, in 0, 0, 0 and 1 child, respectively. Analyzing data from Group I and II, IgA EMA, IgA tTG, AGA and AGG had sensitivity rates of 83%, 74%, 61% and 74%, respectively; the specificity rates were 95%, 100%, 89% and 26%; positive predictive values were 95%, 100%, 88% and 55% and negative predictive values were 82%, 74%, 65% and 45%, respectively. CONCLUSION: IgA tTG is useful for the diagnosis of CD, with sensitivity and specificity rates comparable to those of EMA and this test is well suited for use in tropical countries like India.en_US
dc.description.affiliationDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226 014, India. skyachha@sgpgi.ac.inen_US
dc.identifier.citationYachha SK, Aggarwal R, Srinivas S, Srivastava A, Somani SK, Itha S. Antibody testing in Indian children with celiac disease. Indian Journal of Gastroenterology. 2006 May-Jun; 25(3): 132-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63694
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntibodies, Anti-Idiotypic --blooden_US
dc.subject.meshAutoantibodies --blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCeliac Disease --immunologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDuodenum --pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGliadin --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A --blooden_US
dc.subject.meshImmunoglobulin G --blooden_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshTransglutaminases --blooden_US
dc.titleAntibody testing in Indian children with celiac disease.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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