Maternal and cord blood levels of insulin-like growth factors--I and--II and insulin-like growth factor binding protein-1: correlation with birth weight and maternal anthropometric indices.

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dc.contributor.authorPathmaperuma, A Nen_US
dc.contributor.authorTennekoon, K Hen_US
dc.contributor.authorSenanayake, Len_US
dc.contributor.authorKarunanayake, E Hen_US
dc.date.accessioned2009-05-28T05:36:15Z
dc.date.available2009-05-28T05:36:15Z
dc.date.issued2007-06-19en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractOBJECTIVES: To study the correlation of maternal and cord blood insulin like growth factor (IGF)-I and -II and IGF binding protein (IGFBP)-1 levels with birth weight and maternal anthropometric indices. DESIGN: Longitudinal prospective study. SETTING: Academic Institutions and a Tertiary Care Maternity Hospital. PARTICIPANTS: Women with uncomplicated singleton pregnancy (N = 35) and their newborns. MEASUREMENTS: Maternal weight, height, symphysiofundal height and serum levels of IGF-I, IGF-II, IGFBP-1 were measured thrice during the antenatal period, within 24 h of delivery and at 6 weeks and 6 months postpartum. Newborn anthropometric indices were recorded at birth, and at 6 weeks and 6 months of age. Cord blood levels of IGF-1, IGF-II, IGFBP-1, paternal height and weight, and placental weight measured. RESULTS: Maternal and cord blood IGF-I levels were lower than values reported for Caucasians. All newborns showed adequate growth at birth, and up to 6 months of age. Cord blood IGF-1 positively correlated with chest circumference (r = 0.4532, P = 0.0262), IGFBP-1, negatively with birth weight (r = -0.4024, P = 0.0461) and IGF-II had no effect. Cord blood IGF-I positively correlated with maternal levels at 28 +/- 2 (r = 0.4571, P = 0.0247) and 36 +/- 2 (r = 0.4291, P = 0.0364) weeks of amenorrhoea, whereas IGF-II and IGFBP-1 did not correlate with maternal values. Maternal IGF-I, IGF-II and IGFBP-1 did not correlate with newborn or maternal anthropometric indices. Placental weight correlated significantly with birth weight (r = 0.5299, P = 0.0348) and head circumference (r = 0.5031, P = 0.0470). CONCLUSIONS: Cord blood IGFBP-1 and placental weight appear to be determinants of birth weight variation even among appropriately grown for gestational age newborns.en_US
dc.description.affiliationDepartment of Physiology, Faculty of Medicine, University of Colombo.en_US
dc.identifier.citationPathmaperuma AN, Tennekoon KH, Senanayake L, Karunanayake EH. Maternal and cord blood levels of insulin-like growth factors--I and--II and insulin-like growth factor binding protein-1: correlation with birth weight and maternal anthropometric indices. The Ceylon Medical Journal. 2007 Jun; 52(2): 48-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/48740
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.source.urihttps://www.sljol.info/index.php/CMJ/article/view/1019/949en_US
dc.subject.meshAdulten_US
dc.subject.meshAnthropometryen_US
dc.subject.meshBirth Weighten_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Blooden_US
dc.subject.meshHealth Statusen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInsulin-Like Growth Factor Binding Protein 1 --analysisen_US
dc.subject.meshInsulin-Like Growth Factor I --analysisen_US
dc.subject.meshInsulin-Like Growth Factor II --analysisen_US
dc.subject.meshMaternal Welfareen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Outcomeen_US
dc.subject.meshProspective Studiesen_US
dc.titleMaternal and cord blood levels of insulin-like growth factors--I and--II and insulin-like growth factor binding protein-1: correlation with birth weight and maternal anthropometric indices.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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