Cytokine response to dietary rehabilitation with curd (Indian dahi) & leaf protein concentrate in malnourished children.

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dc.contributor.authorDewan, Pooja
dc.contributor.authorKaur, I R
dc.contributor.authorFaridi, M M A
dc.contributor.authorAgarwal, K N
dc.date.accessioned2011-12-14T05:32:08Z
dc.date.available2011-12-14T05:32:08Z
dc.date.issued2009-07
dc.description.abstractBackground & objectives: Protein energy malnutrition (PEM), an important cause of secondary immune deficiency, is associated with several abnormalities in the immune system including cytokine production. In the present study cytokine levels (both pro- and anti-inflammatory) were evaluated in protein energy malnourished children following nutritional rehabilitation with curd (Indian dahi) and leaf protein concentrate (LPC). Methods: Eighty moderately and severely malnourished children, 1-5 yr of age, received the WHO recommended diet for severe malnutrition, modified according to local dietary habits, containing in addition either curd or micronutrient-rich leaf protein concentrate, for a period of 15 days. Cytokine levels [tumour necrosis factor α (TNFα), interferon γ (IFNγ), interleukin-10 (IL-10), interleukin-4 (IL-4)] were measured before and after dietary rehabilitation. Results: The baseline cytokine levels (TNFα, IFNγ, IL-10 and IL-4) were high in malnourished children. Both the diets caused an increase in serum pro-inflammatory (TNFα, IFNγ), and anti-inflammatory (IL-10) cytokine levels after nutritional rehabilitation. The increase in IL-10 was significant in children receiving curd. There was an insignificant fall in IL-4 levels with both the diets. The cytokine response was comparable in children with moderate and severe malnutrition, as also in children < 2 yr to those between 2-5 yr. Interpretation & conclusions: The study suggests that cytokines (TNFα, IFNγ, IL-10 and IL-4) may serve as biological markers to assess the effect of functional foods like curd or LPC on immunity in malnutrition. Curd may help to maintain the balance in cytokine production by increasing the production of IL-10, and may be considered in place of milk in the nutritional rehabilitation of malnourished children.en_US
dc.identifier.citationDewan Pooja, Kaur I R, Faridi M M A, Agarwal K N. Cytokine response to dietary rehabilitation with curd (Indian dahi) & leaf protein concentrate in malnourished children. Indian Journal of Medical Research. 2009 Jul; 130(1): 31-36.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135860
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2009/july/0704.pdfen_US
dc.subjectcurden_US
dc.subjectcytokinesen_US
dc.subjectdietary rehabilitationen_US
dc.subjectleaf proteinen_US
dc.subjectmalnutritionen_US
dc.subject.meshChild, Preschool
dc.subject.meshCytokines --immunology
dc.subject.meshDairy Products
dc.subject.meshDietary Proteins --administration & dosage
dc.subject.meshDietary Supplements
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshNutritive Value
dc.subject.meshPlant Leaves --chemistry
dc.subject.meshProbiotics --administration & dosage
dc.subject.meshProtein-Energy Malnutrition --diet therapy
dc.subject.meshProtein-Energy Malnutrition --immunology
dc.subject.meshRandom Allocation
dc.titleCytokine response to dietary rehabilitation with curd (Indian dahi) & leaf protein concentrate in malnourished children.en_US
dc.typeArticleen_US
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