Suppression of spermatogenesis by testosterone enanthate in Thai men.

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dc.contributor.authorAribarg, Aen_US
dc.contributor.authorSukcharoen, Nen_US
dc.contributor.authorChanprasit, Yen_US
dc.contributor.authorNgeamvijawat, Jen_US
dc.contributor.authorKriangsinyos, Ren_US
dc.date.accessioned2009-05-27T19:12:21Z
dc.date.available2009-05-27T19:12:21Z
dc.date.issued1996-10-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractTo investigate the effect of testosterone enanthate on suppression of spermatogenesis in Thai men, 17 normal Thai men were given 200 mg testosterone enanthate weekly by intramuscular injection. During treatment, semen was collected regularly to monitor spermatogenesis. Median times for the first semen sample reaching sperm concentration threshold of 5, 3, 1 and 0 million/ml were 58, 70, 84, and 85, respectively. Subsequently, all men became azoospermic. Among 17 men entering the efficacy phase, 14 (82.3%) achieved consistent azoospermic from the beginning of efficacy phase, the remaining 3 (17.7%) were initially severe oligozoospermic but later became azoospermic. Only one case achieved consistent oligozoospermia but did not achieve azoospermia within 6 months. After stopping injection, sperm first reappeared in the ejaculate of formerly azoospermia men at 73 days. Recovery of sperm output to normal sperm concentration (> 20 million/ml) was achieved by all men at a median time of 3.9 months and recovery to their own baseline in one year after the last injection was established in 13/17 (76.5%) at a median time of 4.9 months, respectively. In conclusion, testosterone enanthate alone is effective in suppression of spermatogenesis for male hormonal contraception due to the high rate of azoospermia induced, which is known to ensure reliable and effective, reversible contraception.en_US
dc.description.affiliationDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationAribarg A, Sukcharoen N, Chanprasit Y, Ngeamvijawat J, Kriangsinyos R. Suppression of spermatogenesis by testosterone enanthate in Thai men. Journal of the Medical Association of Thailand. 1996 Oct; 79(10): 624-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40675
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshContraception --methodsen_US
dc.subject.meshContraceptive Agents, Male --administration & dosageen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSperm Counten_US
dc.subject.meshSpermatogenesis --drug effectsen_US
dc.subject.meshTestosterone --administration & dosageen_US
dc.subject.meshThailanden_US
dc.titleSuppression of spermatogenesis by testosterone enanthate in Thai men.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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