Genetic diversity through human leukocyte antigen typing in end‑stage renal disease patients and prospective donors of North India.

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dc.contributor.authorChowdhry, Mohit
dc.contributor.authorMakroo, Raj Nath
dc.contributor.authorKumar, Manoj
dc.date.accessioned2016-08-11T10:27:41Z
dc.date.available2016-08-11T10:27:41Z
dc.date.issued2016-01
dc.description.abstractAs the incidence of end-stage renal disease (ESRD) is rapidly increasing, the demand for dialysis and transplantation has dramatically increased, which has led to concerns about the availability and equitable allocation of kidneys for transplantation. The distribution of HLA-A, B and DR alleles in 148 renal transplant recipients and 191 live related prospective donors from 2009 to 2010 were analyzed. Allele frequencies and haplotype frequencies were calculated in recipients and donors. The prospective donors were further analyzed on the basis of their relationship to the patients and according to the sex ratio. A significant female preponderance was noted in the prospective donor population, most of whom were either siblings or parents of the recipients. On the contrary, the recipient population predominantly comprised of males. The most frequent HLA-A, HLA-B, HLA-DRB1 alleles in renal transplant patients were HLA-A*11, A*02, A*01, A*24; HLA-B*35, B*40, B*44, B*15, B*52, and HLA-DRB1*15, DRB1*07, DRB1*13, DRB1*11 respectively. The most frequent HLA-A, HLA-B, HLA-DRB1 alleles in prospective donors were HLA-A*02, A*11, A*33, A*24; HLA-B*35, B*44, B*40, B*15 and HLA-DRB1*15, DRB1*07, DRB1*11, DRB1*13 respectively. A*11-B*35, A*02-DRB1*15, B*40- DRB1*15 were the most common HLA A-B , HLA A-DR, HLA B-DR haplotypes respectively in renal transplant patients, whereas, A*11-B*35, A*11-DRB1*15, B*44-DRB1*07 were the most common haplotypes in renal donors. In three locus haplotype, HLA-A*02-B*40-DRB1*15 was the most frequent haplotype in patients, whereas, in prospective renal donors HLA-A*33-B*44-DRB1*07 was the most frequent haplotype.en_US
dc.identifier.citationChowdhry Mohit, Makroo Raj Nath, Kumar Manoj. Genetic diversity through human leukocyte antigen typing in end‑stage renal disease patients and prospective donors of North India. Indian Journal of Pathology & Microbiology. 2016 Jan-Mar 59(1): 59-62.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176631
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=1;spage=59;epage=62;aulast=Chowdhryen_US
dc.subjectAllele frequencyen_US
dc.subjectend‑stage renal diseaseen_US
dc.subjecthaplotype frequencyen_US
dc.titleGenetic diversity through human leukocyte antigen typing in end‑stage renal disease patients and prospective donors of North India.en_US
dc.typeArticleen_US
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