Recounting COVID-19 associated complement-mediated coagulopathies: Triggers and controls

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dc.contributor.authorLata, Pen_US
dc.contributor.authorMadhuri, Men_US
dc.contributor.authorAli, Aen_US
dc.contributor.authorKumari, Ben_US
dc.contributor.authorTiwari, Men_US
dc.contributor.authorKumar, Aen_US
dc.contributor.authorHajela, Ken_US
dc.contributor.authorBhushan, Den_US
dc.contributor.authorSharma, S.en_US
dc.date.accessioned2025-05-09T10:45:50Z
dc.date.available2025-05-09T10:45:50Z
dc.date.issued2024-10
dc.description.abstractThe coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a global health crisis, prompting extensive research into its pathogenesis and potential therapeutic interventions. One area of increasing interest is the interaction between SARS-CoV-2 and the complement system, a crucial component of innate immunity. This review explores the intricate relationship between COVID-19 and the complement system, shedding light on how the virus exploits and manipulates the complement components to induce inflammatory responses leading to coagulopathies. The activation of the complement pathway simultaneously activates the coagulation cascade due to the presence of common substrates of mannan-binding serine proteases of the lectin complement system in the coagulation pathway. This cross-talk between the components of the complement and coagulation system further aggravates the dysregulation of immune responses, contributing to the cytokine storm observed in severe COVID-19 cases. A comprehensive understanding of this crosstalk is crucial for developing targeted therapeutic strategies to mitigate the hyperinflammatory state associated with severe disease. Understandings into the molecular mechanisms governing this interaction may pave the way for the development of novel antiviral diagnostics and therapies based on immunomodulatory interventions, offering better management for such cases.en_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Center for Advance Research, King George抯 Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsSchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Tashashila Campus, Indore, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Emergency Medicine, All India Institute of Medical Sciences Patna, Phulwarisharif, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.citationLata P, Madhuri M, Ali A, Kumari B, Tiwari M, Kumar A, Hajela K, Bhushan D, Sharma? S.. Recounting COVID-19 associated complement-mediated coagulopathies: Triggers and controls. Annals of the National Academy of Medical Sciences (India). 2024 Oct; 60(4): 244-249en_US
dc.identifier.issn0379-038X
dc.identifier.issn2454-5635
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245749
dc.languageenen_US
dc.publisherNational Academy of Medical Sciencesen_US
dc.relation.issuenumber4en_US
dc.relation.volume60en_US
dc.source.urihttps://dx.doi.org/10.25259/ANAMS_77_2024en_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectComplement systemen_US
dc.subjectInnate immunityen_US
dc.subjectCoagulopathyen_US
dc.subjectCytokine stormen_US
dc.subjectTherapeutic strategiesen_US
dc.titleRecounting COVID-19 associated complement-mediated coagulopathies: Triggers and controlsen_US
dc.typeJournal Articleen_US
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