Effectiveness of Lactobacillus rhamnosusGG as an Adjunct in the Treatment of Enteric Fever in Children: A Double‑Blinded Randomized Controlled Trial in Southern India

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dc.contributor.authorRajamanickam, Ramyaen_US
dc.contributor.authorJayaraman, Aparnaen_US
dc.contributor.authorSivathanu, Shobhanaen_US
dc.date.accessioned2023-07-14T07:59:04Z
dc.date.available2023-07-14T07:59:04Z
dc.date.issued2023-06
dc.description.abstractIntroduction:Aprobiotic used as an adjunct in Salmonella typhi infection along with antibiotic is postulated to interfere with the virulence and growth of Salmonella. To determine the effectiveness of Lactobacillus rhamnosusGG (LGG), as an adjunct with intravenous ceftriaxone, compared with a placebo in defervescence and toxemia resolution in children with enteric fever. Settings and Design: This hospital‑based randomized double‑blinded controlled trial was conducted among 56 study participants who were children below the age of 12 years, admitted as inpatients with fever and whose blood culture grew S. typhi. Materials and Methods: Study participants were equally allocated into intervention or control group by simple randomization. The intervention group received injection ceftriaxone and oral LGG (probiotic) for 7 days while the control group received an injection ceftriaxone and oral placebo for 7 days. Statistical Analysis: Kaplan–Meier curves and mantel cox log‑rank test were used to compare the duration for defervescence and toxemia resolution after treatment initiation. Results: Mean duration for defervescence in the intervention and control groups was 3.87 (1.57) days and 3.35 (1.19) days, respectively. The mean time taken for the resolution of toxemia was 3.00 (1.15) days in the intervention group and 2.64 (0.87) days in the control group. Conclusions:The addition of oral LGG at a dose of 3 × 109 colony‑forming units for 7 days to the standard antibiotic therapy for enteric fever did not show a significant reduction in the time taken for defervescence (P = 0.099) or resolution of toxemia (P = 0.148)en_US
dc.identifier.affiliationsDepartment of Paediatrics, ESICMC and PGIMSR, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationRajamanickam Ramya, Jayaraman Aparna, Sivathanu Shobhana . Effectiveness of Lactobacillus rhamnosusGG as an Adjunct in the Treatment of Enteric Fever in Children: A Double‑Blinded Randomized Controlled Trial in Southern India. Acta Medica International. 2023 Jun; 10(1): 52-58en_US
dc.identifier.issn2349-0896
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219168
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume10en_US
dc.source.urihttps://doi.org/0.4103/amit.amit_13_23en_US
dc.subjectEnteric feveren_US
dc.subjectLactobacillus rhamnosus GGen_US
dc.subjectprobioticen_US
dc.titleEffectiveness of Lactobacillus rhamnosusGG as an Adjunct in the Treatment of Enteric Fever in Children: A Double‑Blinded Randomized Controlled Trial in Southern Indiaen_US
dc.typeJournal Articleen_US
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