A study of biochemical inflammatory marker of TNF-alpha in hypothyroidism patients

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dc.contributor.authorMahaseth, BKen_US
dc.contributor.authorMishra, Aen_US
dc.contributor.authorMahaseth, Den_US
dc.contributor.authorBera, Cen_US
dc.contributor.authorSharma, AK.en_US
dc.date.accessioned2023-06-27T06:38:33Z
dc.date.available2023-06-27T06:38:33Z
dc.date.issued2022-09
dc.description.abstractBackground: Deranged thyroid function may be caused by autoimmune disorders like auto-immune thyroiditis. The medical staging of the disease shows an extensive display of symptoms like overt hypothyroidism. Various scientific studies had shown that auto-immune thyroiditis may be due to the interaction of cytokines (tumor necrosis factor-alpha � TNF-?). Current studies had shown that TNF-? plays a crucial role in the regulation of thyroid transcription factors. Aims and Objectives: The study aimed to assess the comparative changes of inflammatory markers in diagnosed thyroid patients and control subjects. Materials and Methods: The present study comprises 200 subjects of both sexes whom 00 are healthy controls and 100 are clinically confirmed cases of hypothyroidism, with an age group ranging from 25 to 70 years. Serum TNF-? and serum thyroid stimulating hormone were estimated by ELISA Method. Results: The inflammatory marker (Serum TNF-?) was significantly (P > 0.05) raised in clinically diagnosed hypothyroid patients (4.09 � 0.94) as compared to age and gender match healthy control subjects (3.06 � 0.55). Conclusion: Many studies have shown that inflammatory markers are the primary cause of thyroid function problems. The current cogitation proved that raised serum TNF-? is concerned with the pathogenesis of autoimmune thyroid destruction. It seems that TNF-? is highly significant in the case of Hypothyroidism.en_US
dc.identifier.affiliationsDepartment of Biochemistry, N.C. Medical College and Hospital, Israna, Panipat, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Index Medical College Hospital Research Centre, Indore, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Madhubani Medical College and Hospital, Madhubani, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, N.C. Medical College and Hospital, Israna, Panipat, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Madhav Prasad Tripathi Medical College, Siddharthnagar, Uttar Pradesh, Indiaen_US
dc.identifier.citationMahaseth BK, Mishra A, Mahaseth D, Bera C, Sharma AK.. A study of biochemical inflammatory marker of TNF-alpha in hypothyroidism patients. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Sept; 12(9): 1445-1447en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217707
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber9en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.07352202223072022en_US
dc.subjectHypothyroidismen_US
dc.subjectTumor Necrosis Factor-?en_US
dc.subjectThyroid Stimulating Hormoneen_US
dc.titleA study of biochemical inflammatory marker of TNF-alpha in hypothyroidism patientsen_US
dc.typeJournal Articleen_US
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