Prenatal prevention for severe thalassemia disease at Srinagarind Hospital.

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dc.contributor.authorRatanasiri, Thawalwongen_US
dc.contributor.authorCharoenthong, Chutharaten_US
dc.contributor.authorKomwilaisak, Ratanaen_US
dc.contributor.authorChangtrakul, Yotsombaten_US
dc.contributor.authorFucharoen, Supanen_US
dc.contributor.authorWongkham, Jamrasen_US
dc.contributor.authorKleebkaow, Pilaiwanen_US
dc.contributor.authorSeejorn, Kanoken_US
dc.date.accessioned2009-05-27T20:06:39Z
dc.date.available2009-05-27T20:06:39Z
dc.date.issued2006-10-30en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To evaluate the results and cost-effectiveness of prenatal prevention measurement in severe thalassemia diseases at Srinagarind Hospital. STUDY DESIGN: Descriptive study. SETTING: Antenatal care (ANC) Clinic, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University. SUBJECTS: 1,498 thalassemic screened pregnant women first presenting at ANC Clinic at gestational age less than 17 weeks. MATERIAL AND METHOD: Medical records of thalassemic screened pregnant women between February 2002 and February 2005 were analyzed. Those with a value of mean corpuscular volume (MCV) less than 80 fl, or positive dichlorophenol indophenol precipitation test (KKU-DCIP Clear Reagent Kit) underwent hemoglobin (Hb) typing by high performance liquid chromatography (HPLC) together with thalassemia investigation (complete blood count, MCV and Hb typing) of their husbands and to identify couples at risk of 3 severe thalassemia diseases; Hb Bart's hydrops fetalis, homozygous, -thalassemia and, -thalassemia/ Hb E disease. Then they were advised to undergo DNA analysis and, if they had fetal risk, appropriate prenatal diagnosis was offered. MAIN OUTCOME MEASURE: Number of affected fetuses detected by prenatal diagnosis. RESULTS: Nine hundred and ninety six pregnant women (66.49%) were positive on screening. Of these, 642 (64.46%) had thalassemia investigation done with their spouses. There were 19 couples at risk (1.27% of total screened pregnant women) for having fetal severe thalassemia disease from initial laboratory results. Most of them were, -thalassemia/ Hb E diseases. We found only 10 pregnant women (52.63%) that had undergone prenatal diagnosis. The consequent results were two affected fetuses (20%), one was Hb Bart's hydrops fetalis, and the other was, o-thalassemia/ Hb E disease. In these cases, their parents decided to discontinue the pregnancy. Our prevention program could save 1.14 million bahts for the cost of treatment in two prevented severe thalassemia cases. CONCLUSION: The prenatal prevention program of severe thalassemia disease at Srinagarind Hospital can effectively detect affected fetuses and reduce severe thalassemia disease, which is a major health problem in Thailand.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.en_US
dc.identifier.citationRatanasiri T, Charoenthong C, Komwilaisak R, Changtrakul Y, Fucharoen S, Wongkham J, Kleebkaow P, Seejorn K. Prenatal prevention for severe thalassemia disease at Srinagarind Hospital. Journal of the Medical Association of Thailand. 2006 Oct; 89 Suppl 4(): S87-93en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/42389
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screening --economicsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Care --economicsen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshProgram Evaluationen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshThailanden_US
dc.subject.meshThalassemia --diagnosisen_US
dc.titlePrenatal prevention for severe thalassemia disease at Srinagarind Hospital.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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