Migraine & paediatric obesity: a plausible link.

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dc.contributor.authorRavid, Sarit
dc.date.accessioned2015-01-15T11:00:55Z
dc.date.available2015-01-15T11:00:55Z
dc.date.issued2014-03
dc.description.abstractObesity and migraine are both highly prevalent disorders in the general population, influenced by genetic and environmental risk factors. In recent studies, obesity was found to be a strong risk factor for transformed migraine and, among migraineurs, obesity was associated with frequent headaches and higher disability scores. Suggested mechanisms included: (i) obesity as a pro-inflammatory state may be associated with neurovascular inflammation in patients with migraine; (ii) elevated levels of plasma calcitonin gene-related peptide (CGRP) in obese individuals may play a role as an important post-synaptic mediator of trigeminovascular inflammation in migraine; (iii) dismodulation in the hypothalamic neuropeptide, orexin, in obese persons may be associated with increased susceptibility to neurogenic inflammation causing migraine attacks; and (iv) leptin and adiponectin can activate proinflammatory cytokine release that is involved in the pathogenesis of migraine. In addition, both conditions are associated with psychiatric co-morbidities, such as depression and anxiety, that can further increase headache frequency and disability. Therefore, the effect of obesity on migraine outcome is important. Weight and BMI should be measured and calculated in all children presenting with migraine, and weight control should be a part of the treatment.en_US
dc.identifier.citationRavid Sarit. Migraine & paediatric obesity: a plausible link. Indian Journal of Medical Research. 2014 Mar;139 (3): 343-348.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155174
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069728/en_US
dc.subjectBody mass indexen_US
dc.subjectchildrenen_US
dc.subjectdisabilityen_US
dc.subjectheadacheen_US
dc.subjectmigraineen_US
dc.subjectobesityen_US
dc.subjectproinflammatory cytokineen_US
dc.titleMigraine & paediatric obesity: a plausible link.en_US
dc.typeArticleen_US
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