Polymorphisms in cytotoxic T-lymphocyte associated antigen 4 gene does not affect scytotoxic T-lymphocyte associated antigen 4 levels in human papillomavirus-infected women with or without cervical cancer

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dc.contributor.authorWagh, Pen_US
dc.contributor.authorKulkarni, Pen_US
dc.contributor.authorKerkar, Sen_US
dc.contributor.authorWarke, Hen_US
dc.contributor.authorChaudhari, Hen_US
dc.contributor.authorDeodhar, Ken_US
dc.contributor.authorRekhi, Ben_US
dc.contributor.authorTongaonkar, Hen_US
dc.contributor.authorMania-Pramanik, Jen_US
dc.date.accessioned2020-04-23T07:36:18Z
dc.date.available2020-04-23T07:36:18Z
dc.date.issued2018-06
dc.description.abstractBackground: Cervical cancer (CaCx) is the second most common cancer in Indian women. Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) + 49 AA polymorphism is known to be associated with CaCx. Current attempt is to use immunotherapy for the treatment of metastatic melanoma and metastatic castration-resistant prostate cancer, i.e., blocking of CTLA-4 using a fully human monoclonal CTLA-4 antibody to disrupt its inhibitory signal. This allows the CTLs to destroy the cancer cells. There is no information available on the soluble level of CTLA-4 on which the immunotherapy is targeted. This is specifically in Indian population including cases with CaCx. Objective: The aim of this study is to evaluate the levels of soluble CTLA-4 (sCTLA-4) in human papillomavirus (HPV)-infected women with or without CaCx and their association with the polymorphism at CTLA-4 + 49 A/G and CTLA-4 ?318 C/T genotypes. Materials and Methods: This is an exploratory case–control study involving two groups of HPV-infected women, the cases were with invasive CaCx and the control group was women with the healthy cervix. sCTLA-4 levels were measured using ELISA in 92 CaCx cases and 57 HPV-positive women with the healthy cervix. Results: Both cases and controls have similar sCTLA-4 levels. Comparison of CTLA-4 + 49A/G and ?318 C/T genotypes with sCTLA-4 levels among cases and control also did not show any statistically significant difference. Conclusion: The present study suggests sCTLA-4 levels are not affected by a polymorphism at + 49 A>G CTLA-4. Hence, levels of CTLA-4 are similar in both CaCx cases and control group.en_US
dc.identifier.affiliationsDepartment of Infectious Diseases Biology, ICMR-National Institute for Research in Reproductive Health, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Infectious Diseases Biology, ICMR-National Institute for Research in Reproductive Health, Mumbai, Maharashtra, India; Department of Urology, University of California, San Francisco, California, USAen_US
dc.identifier.affiliationsDepartment of Gynecology and Obstetrics, Seth G. S. Medical College, KEM Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment Urology and Gynecologic Oncology, Tata Memorial Hospital; Department of Surgery, Hinduja Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationWagh P, Kulkarni P, Kerkar S, Warke H, Chaudhari H, Deodhar K, Rekhi B, Tongaonkar H, Mania-Pramanik J. Polymorphisms in cytotoxic T-lymphocyte associated antigen 4 gene does not affect scytotoxic T-lymphocyte associated antigen 4 levels in human papillomavirus-infected women with or without cervical cancer. Indian Journal of Medical Microbiology. 2018 Jun; 36(2): 207-210en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198755
dc.languageenen_US
dc.publisherIndian Association of Medical Microbiologistsen_US
dc.relation.issuenumber2en_US
dc.relation.volume36en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmm.IJMM_17_220en_US
dc.subjectCervical canceren_US
dc.subjectpolymorphismen_US
dc.subjectsoluble cytotoxic T-lymphocyte associated antigen 4en_US
dc.titlePolymorphisms in cytotoxic T-lymphocyte associated antigen 4 gene does not affect scytotoxic T-lymphocyte associated antigen 4 levels in human papillomavirus-infected women with or without cervical canceren_US
dc.typeJournal Articleen_US
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