Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma.

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dc.contributor.authorGadage, Vijaya S
dc.contributor.authorSubramanian, P G
dc.contributor.authorGalani, Komal S
dc.contributor.authorSehgal, Kunal K
dc.contributor.authorJohari, Sachin P
dc.contributor.authorGhogale, Vijay S
dc.contributor.authorBadrinath, Y
dc.contributor.authorAshok, K
dc.contributor.authorGujral, Sumeet
dc.date.accessioned2012-10-11T10:37:03Z
dc.date.available2012-10-11T10:37:03Z
dc.date.issued2011-07
dc.description.abstractAnaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.en_US
dc.identifier.citationGadage Vijaya S, Subramanian P G, Galani Komal S, Sehgal Kunal K, Johari Sachin P, Ghogale Vijay S, Badrinath Y, Ashok K, Gujral Sumeet. Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 599-602.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142055
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=599;epage=602;aulast=Gadageen_US
dc.subjectAnaplastic large cell lymphomaen_US
dc.subjectflow cytometryen_US
dc.subjectleukemic phaseen_US
dc.subject.meshAdolescent
dc.subject.meshAntigens, CD30 --analysis
dc.subject.meshAntigens, CD45 --analysis
dc.subject.meshChild
dc.subject.meshDisease Progression
dc.subject.meshFemale
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshInterleukin-2 Receptor alpha Subunit --analysis
dc.subject.meshLeukemia, Lymphoid --pathology
dc.subject.meshLeukocytes, Mononuclear --chemistry
dc.subject.meshLymphoma, Large-Cell, Anaplastic --complications
dc.subject.meshLymphoma, Large-Cell, Anaplastic --diagnosis
dc.subject.meshLymphoma, Large-Cell, Anaplastic --pathology
dc.subject.meshMale
dc.subject.meshReceptor Protein-Tyrosine Kinases --metabolism
dc.subject.otherLeukemia, Lymphoid --diagnosis
dc.titleLeukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma.en_US
dc.typeArticleen_US
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