Comparing Thyroid Abnormalities with Severity of Chronic Renal Failure
| dc.contributor.author | Dakre, Abhijit | en_US |
| dc.contributor.author | Idhol, Sagar | en_US |
| dc.date.accessioned | 2020-11-18T10:29:12Z | |
| dc.date.available | 2020-11-18T10:29:12Z | |
| dc.date.issued | 2020-01 | |
| dc.description.abstract | Background Thyroid dysfunction affects renal physiology and development, whereas kidney disease could resultin thyroid dysfunction. Disorders of the thyroid and kidney may co-exist with common etiological factors. In addition,treatment strategies of one disease may affect those of other organ. Decrease in iodothyronines is associated withreduced blood flow to kidneys and decreased glomerular filtration rate(GFR) along with alteration in tubularreabsorption resulting in decrease in water excretion. Aim To estimate thyroid hormone levels i.e. T3, T4 & TSH inCRF. Methods An observational study was carried out at the Dr. Panjabrao Deshmukh Memorial MedicalCollege, Amravati, Maharashtra in and out patients of the dialysis unit. The study was carried out for a period from12th of August, 2019 to 12th of December 2019. The patients were divided into two groups namely case and controlwith 35 male patients each. In the case group patients having serum creatinine >5.5md/dl and urea >55 mg/dl withsymptoms of chronic renal failure were included. However, in the control group 35 healthy male patients wereincluded in the study. Results It was identified that Serum creatinine and T3 and Serum creatinine and T4 showednegative correlation. This implies that if the serum creatinine level rises T3 and T4 levels will fall and vice versa.In the case group majority of the patients had normal thyroid function while 14.28% had hypothyroidism.Hypothyroidism was present in 5 of the patients with serum creatinine >6.0 mg/dl. Conclusion In the light of theresults it was identified that the mean T3 and T4 levels decreased while TSH levels increased significantly in thecase group as compared to the control group. Furthermore, it was identified in the study that the levels of T3, T4decreased and TSH increased as severity renal failure increased. | en_US |
| dc.identifier.affiliations | Department of Medicine, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, Maharashtra, India | en_US |
| dc.identifier.citation | Dakre Abhijit, Idhol Sagar. Comparing Thyroid Abnormalities with Severity of Chronic Renal Failure. Journal of Pharmaceutical and Biomedical Sciences. 2020 Jan; 10(1): 1-5 | en_US |
| dc.identifier.issn | 2230-7885 | |
| dc.identifier.place | India | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/215729 | |
| dc.language | en | en_US |
| dc.publisher | Lawarence Press Pvt. Ltd. | en_US |
| dc.relation.issuenumber | 1 | en_US |
| dc.relation.volume | 10 | en_US |
| dc.source.uri | https://lawarencepress.com/ojs/index.php/JPBMS/article/view/598/pdf_284 | en_US |
| dc.subject | Chronic renal failure | en_US |
| dc.subject | thyroid dysfunction | en_US |
| dc.subject | chronic kidney disease | en_US |
| dc.title | Comparing Thyroid Abnormalities with Severity of Chronic Renal Failure | en_US |
| dc.type | Journal Article | en_US |
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