Prevalence of extended spectrum beta lactamases in Salmonella species isolated from patients with acute gastroenteritis.
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Date
2010-09
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Abstract
Introduction and aims Extended-spectrum β-lactamases (ESBLs) continue to be a major problem world wide, conferring resistance to the expanded-spectrum cephalosporins. They are increasingly associated with genus Salmonella. This
study aimed to determine the prevalence of ESBLs in
Salmonella isolates in our region by phenotypic methods.
Methods One thousand stool samples of acute gastroenteritis
patients were screened and 42 strains of Salmonella (19
S. typhimurium, 14 S. enteritidis, 5 S. typhi, 3 S. paratyphi B
3 and 1 S. infantis) were detected.
Results In the 3rd generation cephalosporin resistant Salmonella
stains, ESBL was detected by double disc synergy
test in ten isolates and by phenotypic confirmatory test in
eight isolates of Salmonella. Drug resistance to various
antibiotics was noted both among ESBL producers and
non-ESBL producers. Resistance to chloramphenicol, nalidixic
acid, norfloxacin and ciprofloxacin was noted in
ESBL producers (n=4, 3, 8 and 8 of eight cases
respectively) and in non-ESBL producers (n=10, 9, 16
and 13 of 34 cases, respectively). Quinolone resistance was
significantly higher in ESBL producers while imipenem
and cotrimoxazole resistance was significantly higher in
non-ESBL producers. ESBL positive Salmonella isolates
were found to be sensitive to amikacin and amoxyclav.
Conclusion The proper and regular monitoring of drug
resistance ESBL production among Salmonella strains were necessary for the effective therapeutic outcome.
Description
Keywords
Beta lactamases, Diarrhea, Multidrug resistance
Citation
Uma Babu, Prabhakar Kesani, Rajendran Sadaiyappan, Sarayu Yelavarthi Lakshmi. Prevalence of extended spectrum beta lactamases in Salmonella species isolated from patients with acute gastroenteritis. Indian Journal of Gastroenterology. 2010 Sept-Oct; 29(5): 201-204.