Gestational diabetes mellitus causes dyslipidemia in late trimester: mini review

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dc.contributor.authorS., Poonguzhalaien_US
dc.contributor.authorP., Kalyanikutty K.en_US
dc.date.accessioned2020-10-16T08:01:51Z
dc.date.available2020-10-16T08:01:51Z
dc.date.issued2020-01
dc.description.abstractThe incidence of gestational diabetes mellitus (GDM) is increasing rapidly worldwide. Many women with gestational diabetes mellitus are likely to have type 2 diabetes. With the extensive management protocol for GDM we are able to obtain a good glycaemic control but still excess morbidity prevails among GDM pregnancy compared to normal pregnancy. This may be due to the dysfunction of lipid metabolism. Changes in carbohydrate and lipid metabolism occur during pregnancy to ensure a continuous supply of nutrients to the growing fetus despite intermittent maternal food intake. Exaggerated reduction in insulin sensitivity in the peripheral tissues combined with peripheral adipose tissue lipolysis in GDM pregnancy than normal pregnancy results in increased maternal lipoprotein concentrations and elevated lipoprotein triglyceride content. An altered lipid profile on the maternal side would modulate the quantity and quality of lipids being transferred to the fetus. Hypertriacylglycerolemia in gestational diabetes mellitus has been related to a significant risk of having neonates that are large for gestational age and it is considered as a major cause of preeclampsia in the late gestational age. So, the recent researchers emphasize on targeting lipid metabolism in pregnant women with GDM to avoid the adverse outcomes of pregnancy.en_US
dc.identifier.affiliationsDepartment of Physiology, JIPMER, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, Calicut Govt Medical College, Kerala, Indiaen_US
dc.identifier.citationS. Poonguzhalai, P. Kalyanikutty K.. Gestational diabetes mellitus causes dyslipidemia in late trimester: mini review. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Jan; 9(1): 453-457en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207387
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20195600en_US
dc.subjectDyslipidaemiaen_US
dc.subjectGestational diabetes mellitusen_US
dc.subjectLarge for date babyen_US
dc.subjectPreeclampsiaen_US
dc.titleGestational diabetes mellitus causes dyslipidemia in late trimester: mini reviewen_US
dc.typeJournal Articleen_US
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