Evaluation of Hepatoprotective Effect of Essential Oil of Etlingera Fenzlii (Kurz) Skronick & M. Sabu (Zingiberaceae)

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dc.contributor.authorSudhakaran, Anjuen_US
dc.contributor.authorKumar, K.B. Rameshen_US
dc.contributor.authorRadha, R.K.en_US
dc.date.accessioned2020-04-23T07:40:22Z
dc.date.available2020-04-23T07:40:22Z
dc.date.issued2019-10
dc.description.abstractBackground: Etlingera fenzlii (Kurz) Skronick & M. Sabu (Zingiberaceae), is an endemic species of theAndaman Nicobar Islands. Used by the nomadic tribes, shompens as honey bee repellent and also usedagainst malaria fever, gastrointestinal disorders, wherein the root and flower is boiled in water and used towash the uterus after child birth.Aim: The present study was aimed to investigate the essential oil of Etlingera fenzlii (EOEF) in ethanolinduced hepatotoxicity in Wistar albino rats and silymarin was used as positive control.Methods: Standard drug (Silymarin), essential oil, ethanol were administered orally for 28 days. On 28th dayanimals were sacrificed and blood was collected for assessment of AST, ALT, ALP, total protein, albumin,globulin and histopathological changes in the liver of different groups were also studied.Results: Oral administration of ethanol significantly increased biochemical parameters such as AST, ALT,ALP levels and whereas reverse was observed with test compounds (Silymarin and essential oil).Histopathological studies further substantiate the hepatoprotective effect of E.fenzlii essential oil.Conclusion: Our observation indicates that essential oil of E.fenzlii shows hepatoprotective activity comparedto standard drug silymarin. The present study thus provides a scientific rationale for the traditional use ofE.fenzlii in the management of liver disorders.en_US
dc.identifier.affiliationsBiotechnology & Bioinformatics Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute,Palode, Thiruvananthapuram, Kerala – 695 562, Indiaen_US
dc.identifier.affiliationsPhytochemistry & Phytopharmacology Division,Jawaharlal Nehru Tropical Botanic Garden and Research Institute,Palode, Thiruvananthapuram, Kerala – 695 562, Indiaen_US
dc.identifier.citationSudhakaran Anju, Kumar K.B. Ramesh, Radha R.K.. Evaluation of Hepatoprotective Effect of Essential Oil of Etlingera Fenzlii (Kurz) Skronick & M. Sabu (Zingiberaceae). Indian Journal of Physiology and Pharmacology. 2019 Oct; 4: 309-316en_US
dc.identifier.issn0019-5499
dc.identifier.issn2582 – 2799
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198956
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber4en_US
dc.relation.volume63en_US
dc.source.urihttps://ijpp.com/IJPP%20archives/2019_63_4/309-316.pdfen_US
dc.titleEvaluation of Hepatoprotective Effect of Essential Oil of Etlingera Fenzlii (Kurz) Skronick & M. Sabu (Zingiberaceae)en_US
dc.typeJournal Articleen_US
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