Antibody response of children immunized with poliovaccines: an evaluation using two strains of poliovirus type 1.

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dc.contributor.authorDeshpande, J Men_US
dc.contributor.authorDave, K Hen_US
dc.date.accessioned1992-09-01en_US
dc.date.accessioned2009-05-27T06:25:20Z
dc.date.available1992-09-01en_US
dc.date.available2009-05-27T06:25:20Z
dc.date.issued1992-09-01en_US
dc.description.abstractNeutralizing antibody response of children immunized with either OPV (3 doses), or IPV (2 doses) was evaluated against poliovirus type 1 Sabin vaccine strain and a local neurovirulent isolate. Both vaccines elicited significantly better antibody response against the vaccine strain than against the neurovirulent isolate. Moreover, approximately 35 per cent of sera contained very low levels of antibody against the virulent virus in spite of good antibody titre against the vaccine strain. The observed difference in antibody response to the wild and the vaccine strains was significant. The differential immune response could be one of the reasons of paralytic disease observed even after administration of OPV (3), in some children if infecting virus dose is high, as in case of urban slums in endemic areas.en_US
dc.description.affiliationEnterovirus Research Centre, Bombay.en_US
dc.identifier.citationDeshpande JM, Dave KH. Antibody response of children immunized with poliovaccines: an evaluation using two strains of poliovirus type 1. Indian Journal of Medical Research. 1992 Sep; 95(): 216-20en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16143
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAntibodies, Viral --blooden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshEvaluation Studies as Topicen_US
dc.subject.meshHumansen_US
dc.subject.meshPoliomyelitis --immunologyen_US
dc.subject.meshPoliovirus --immunologyen_US
dc.subject.meshPoliovirus Vaccine, Inactivated --immunologyen_US
dc.subject.meshPoliovirus Vaccine, Oral --immunologyen_US
dc.subject.meshSpecies Specificityen_US
dc.subject.meshVaccinationen_US
dc.titleAntibody response of children immunized with poliovaccines: an evaluation using two strains of poliovirus type 1.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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