A newly designed biliary brachytherapy drainage catheter for patients with malignant biliary obstruction: A pilot study

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dc.contributor.authorJiao, Dechaoen_US
dc.contributor.authorZhou, Xueliangen_US
dc.contributor.authorLi, Zongmingen_US
dc.contributor.authorBi, Yonghuaen_US
dc.contributor.authorZhang, Quanhuien_US
dc.contributor.authorLi, Jingen_US
dc.contributor.authorLi, Leien_US
dc.contributor.authorRen, Jianzhuangen_US
dc.contributor.authorHan, Xinweien_US
dc.date.accessioned2020-11-18T10:08:18Z
dc.date.available2020-11-18T10:08:18Z
dc.date.issued2020-05
dc.description.abstractAim: Self.expandable metallic stent (SEMS) placement has been considered as the preferred treatment to relieve jaundice in nonsurgical patients. However, 50% of stents become stenosed within 3.6 months due to tumor ingrowth and epithelial hyperplasia. This study aims to evaluate the feasibility and efficacy of a newly designed brachytherapy biliary drainage catheter (BBDC) loaded with 125I seeds for palliation of malignant biliary obstruction (MBO). Methods: In this prospective study, patients with unresectable MBO underwent BBDC placement after SEMS placement at our center from September 2017 to April 2019. Results: A total of 21 patients with MBO were enrolled. The technical and clinical success rates were 100%. Total bilirubin, direct bilirubin, alanine aminotransferase, alkaline phosphatase, cancer antigen 19.9, and carcinoembryonic antigen levels significantly decreased during the 1.month follow.up (P < 0.05). Four patients (19%) had minor complications. During the median follow.up of 299 days, 13 patients (61.9%) developed stent occlusion. The 6.month stent patency and survival rates were 73.5% and 79.2%, respectively. The median stent patency and survival were 279 and 454 days, respectively. Conclusion: The use of BBDC loaded with 125I seeds is a feasible and effective method to prolong biliary stent patency in patients with MBOen_US
dc.identifier.affiliationsDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Chinaen_US
dc.identifier.citationJiao Dechao, Zhou Xueliang, Li Zongming, Bi Yonghua, Zhang Quanhui, Li Jing, Li Lei, Ren Jianzhuang, Han Xinwei. A newly designed biliary brachytherapy drainage catheter for patients with malignant biliary obstruction: A pilot study. Journal of Cancer Research and Therapeutics. 2020 May; 16(2): 286-291en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213815
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_804_19en_US
dc.subject125I seeden_US
dc.subjectbiliary stenten_US
dc.subjectbrachytherapyen_US
dc.subjectcatheter drainageen_US
dc.subjectclinical studyen_US
dc.subjectmalignant biliary obstructionen_US
dc.titleA newly designed biliary brachytherapy drainage catheter for patients with malignant biliary obstruction: A pilot studyen_US
dc.typeJournal Articleen_US
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