Predictors of treatment failure in severe pneumonia treated with Ampicillin in tertiary care center

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dc.contributor.authorM., Lakshmien_US
dc.contributor.authorA., Manu M.en_US
dc.contributor.authorY., Kalpana R.en_US
dc.contributor.authorSabapathy, Saralaen_US
dc.contributor.authorD., Rekha T.en_US
dc.date.accessioned2020-09-24T07:43:52Z
dc.date.available2020-09-24T07:43:52Z
dc.date.issued2019-05
dc.description.abstractBackground: Pneumonia affects 156 million children under five years every year and is the leading cause of mortality in this age group. It emphasizes the need to identify high risk factors for Treatment Failure so as to treat them aggressively. The objective of this study was to assess factors influencing treatment failure in severe pneumonia treated with Ampicillin.Methods: Prospective observational study, in which 235 children with severe pneumonia between 2 months to 60 months were enrolled and started with intravenous Ampicillin as per WHO protocol. If no clinical improvement was seen after 48 hours, it was taken as treatment failure and managed accordingly.Results: Among 235 children, 43(18.2%) did not respond to Ampicillin. Among treatment failure cases males were 20 (46.5%) and females were 23 (53.6%). All the following parameters were statistically significant(p<0.05). Majority of 23(53.4%) were between 2 to 12 months. 13(30.2%) were incompletely immunized. MAM were 23(53.4%) and 22(51.1%) cases had signs of Rickets. 34(79.1%) had Anemia out of which 22(64%) had moderate anemia. 39(90.6%) children had fever and hypoxia at admission.Conclusions: Infancy, malnutrition, severity of anemia, rickets, lack of immunization, hypoxia at baseline were significant predictors of treatment failure in severe pneumonia. Strengthening immunization and improving nutritional status may improve the outcome. Children with above risk factors require vigilant monitoring.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Bangalore Medical College and Research Institute, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationM. Lakshmi, A. Manu M., Y. Kalpana R., Sabapathy Sarala, D. Rekha T.. Predictors of treatment failure in severe pneumonia treated with Ampicillin in tertiary care center. International Journal of Contemporary Pediatrics. 2019 May; 6(3): 1085-1089en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204045
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20191479en_US
dc.subjectAmpicillinen_US
dc.subjectAnemiaen_US
dc.subjectHypoxiaen_US
dc.subjectImmunizationen_US
dc.subjectModerate acute malnutritionen_US
dc.subjectPneumoniaen_US
dc.subjectRicketsen_US
dc.subjectSevere treatment failureen_US
dc.titlePredictors of treatment failure in severe pneumonia treated with Ampicillin in tertiary care centeren_US
dc.typeJournal Articleen_US
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