Molecular studies on dengue viruses detected in patients from Central India

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dc.contributor.authorBarde, PVen_US
dc.contributor.authorShukla, MKen_US
dc.contributor.authorJoshi, Pen_US
dc.contributor.authorSahare, Len_US
dc.contributor.authorUkey, MJen_US
dc.date.accessioned2020-04-23T07:37:47Z
dc.date.available2020-04-23T07:37:47Z
dc.date.issued2019-03
dc.description.abstractPurpose: Dengue viruses (DENVs), the causative agents of dengue (DEN), are classified into four serotypes and several genotypes. Identifying circulating serotypes and genotypes has clinical and epidemiological importance; however, limited information in this regard is available from Central India. This laboratory-based study was done to fill this lacuna. Materials and Methods: The samples collected in the acute phase of illness were subjected to DEN NS1 ELISA, and NS1-positive samples (n = 80) were subjected to serotyping; representative samples from each serotype were sequenced to identify genotypes. Results: Seventy-one (88.75%) samples could be serotyped. All the four DENV serotypes with dominance of DENV-3 (n = 33; 47%) were detected. DENV-4 was detected after a gap of 3 years. Cases with multiple DENV serotype infection were identified. Genotyping showed that DENV-1 belonging to genotype III, DENV-2 cosmopolitan (IV), DENV-3 genotype III lineage C and DENV-4 genotype I were in circulation in the year 2016. Conclusion: Our study documents the molecular characteristics of DENV circulating in the area. Detection of heterologous DENV serotype with dominance of DENV-3 emphasises the need for regular molecular monitoring.en_US
dc.identifier.affiliationsDivision of Virology and Zoonoses, ICMR-National Institute of Research in Tribal Health, Jabalpur, Madhya Pradesh, Indiaen_US
dc.identifier.citationBarde PV, Shukla MK, Joshi P, Sahare L, Ukey MJ. Molecular studies on dengue viruses detected in patients from Central India. Indian Journal of Medical Microbiology. 2019 Mar; 37(1): 12-18en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198853
dc.languageenen_US
dc.publisherIndian Association of Medical Microbiologistsen_US
dc.relation.issuenumber1en_US
dc.relation.volume37en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmm.IJMM_18_377en_US
dc.subjectCentral Indiaen_US
dc.subjectdengueen_US
dc.subjectgenotypeen_US
dc.subjectserotype/sen_US
dc.titleMolecular studies on dengue viruses detected in patients from Central Indiaen_US
dc.typeJournal Articleen_US
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