OSSN in South India: Clinical presentation, treatment outcomes, and histopathologic correlations

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dc.contributor.authorPrasad, P V Tejaswien_US
dc.contributor.authorKrishnan, Shanti Radhaen_US
dc.contributor.authorRadhakrishnan, Naveenen_US
dc.contributor.authorBhaskaran, Sahithyaen_US
dc.contributor.authorPrajna, N Venkateshen_US
dc.date.accessioned2025-06-19T05:52:06Z
dc.date.available2025-06-19T05:52:06Z
dc.date.issued2025-04
dc.description.abstractPurpose: This study aimed to analyze the clinical presentation, treatment outcomes, and histopathology features of ocular surface squamous neoplasia (OSSN) in a South Indian population and correlate the area of lesions to the histopathological grade/severity of carcinoma in situ (CIN) and squamous cell carcinoma (SqCC) invasive and noninvasive tumors. Methods: The study was a retrospective cross?sectional study. The study reviewed electronic medical records (EMRs) of 99 eyes of 99 South Indian patients who underwent en bloc excision and biopsy for tumors in the corneal and conjunctival epithelium with suspicion of OSSN over 1 year from January 2019 to December 2019. Postoperatively, patients were treated with three cycles of topical 0.04% mitomycin C eye drops. Sixty?three had requisite EMR data with a follow?up period of 1 year. Results: Patients had equal gender distribution with an age range of 28–83 years. The most common clinical variant was leukoplakic lesion, and the area of the lesion was the only predicting factor for SqCC and CIN. Conclusion: Bigger (T2) lesions should be strongly suspected for OSSN and promptly excised. Histopathologic analysis should be performed, and post?op topical mitomycin C or interferon alpha 2b is administered to avoid recurrence. In this study, by correlating the area of the lesion, we introduce a new variable that may aid in clinical prognostication alongside the AJCC classification.en_US
dc.identifier.affiliationsDepartment of Cornea, Ophthalmic Pathology Laboratory Services, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Head, Ophthalmic Pathology Laboratory Services, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Cornea, Aravind Eye Hospital, Pondicherry, Indiaen_US
dc.identifier.affiliationsPediatric Ophthalmology and Strabismus, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Cornea, Ophthalmic Pathology Laboratory Services, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.citationPrasad P V Tejaswi, Krishnan Shanti Radha, Radhakrishnan Naveen, Bhaskaran Sahithya, Prajna N Venkatesh. OSSN in South India: Clinical presentation, treatment outcomes, and histopathologic correlations. Indian Journal of Ophthalmology. 2025 Apr; 73(4): 586-589en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249880
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume73en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_909_24en_US
dc.subjectConjunctival carcinomaen_US
dc.subjectconjunctival intraepithelial neoplasmen_US
dc.subjecthistopathologyen_US
dc.subjectocular surface squamous neoplasiaen_US
dc.titleOSSN in South India: Clinical presentation, treatment outcomes, and histopathologic correlationsen_US
dc.typeJournal Articleen_US
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