Intrinsic disorder in flaviviral capsid proteins and its role in pathogenesis

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dc.contributor.authorSUNDAR, ANIRUDHen_US
dc.contributor.authorUMASHANKAR, PAVITHRAen_US
dc.contributor.authorSANKAR, PRIYANKAen_US
dc.contributor.authorRAMASAMY, KAVITHAen_US
dc.contributor.authorVENKATARAMAN, SANGITAen_US
dc.date.accessioned2024-11-30T11:24:42Z
dc.date.available2024-11-30T11:24:42Z
dc.date.issued2024-05
dc.description.abstractA high level of disorder in many viral proteins is a direct consequence of their small genomes, which makes interaction with multiple binding partners a necessity for infection and pathogenicity. A segment of the flaviviral capsid protein (C), also known as the molecular recognition feature (MoRF), undergoes a disorder-to-order transition upon binding to several protein partners. To understand their role in pathogenesis, MoRFs were identified and their occurrence across different flaviviral capsids were studied. Despite lack of sequence similarities, docking studies of Cs with the host proteins indicate conserved interactions involving MoRFs across members of phylogenetic subclades. Additionally, it was observed from the protein–protein networks that some MoRFs preferentially bind proteins that are involved in specialized functions such as ribosome biogenesis. The findings point to the importance of MoRFs in the flaviviral life cycle, with important consequences for disease progression and suppression of the host immune system. Potentially, they might have impacted the way flaviviruses evolved to infect varied hosts using multiple vectors.en_US
dc.identifier.affiliationsDepartment of Biotechnology, Anna University, Guindy, Chennai 600 025, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology, Anna University, Guindy, Chennai 600 025, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology, Anna University, Guindy, Chennai 600 025, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology, Anna University, Guindy, Chennai 600 025, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology, Anna University, Guindy, Chennai 600 025, Indiaen_US
dc.identifier.citationSUNDAR ANIRUDH, UMASHANKAR PAVITHRA, SANKAR PRIYANKA, RAMASAMY KAVITHA, VENKATARAMAN SANGITA. Intrinsic disorder in flaviviral capsid proteins and its role in pathogenesis. Journal of Biosciences. 2024 May; 49: 1-12en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237975
dc.languageenen_US
dc.publisherThe Indian Academy of Sciencesen_US
dc.relation.volume49en_US
dc.source.urihttps://doi.org/10.1007/s12038-024-00439-6en_US
dc.subjectInteractionen_US
dc.subjectintrinsically disordered proteinsen_US
dc.subjectmolecular recognition featureen_US
dc.subjectstructureen_US
dc.subjectvirusen_US
dc.titleIntrinsic disorder in flaviviral capsid proteins and its role in pathogenesisen_US
dc.typeJournal Articleen_US
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