Study of the prevalence of isolated vitamin B12 deficiency related dementia in patients presenting to a tertiary care hospital

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dc.contributor.authorReddy, Patirla Devendraen_US
dc.contributor.authorSeela, Pranavendra Nathen_US
dc.contributor.authorMaske, Pravin Gulab Raoen_US
dc.date.accessioned2020-04-09T07:43:57Z
dc.date.available2020-04-09T07:43:57Z
dc.date.issued2020-04
dc.description.abstractBackground: Objective of the study was to determine the prevalence of Isolated B12deficient dementia in patients presenting to a tertiary care hospital. The MMSE was much lower in B12 deficiency compared to irreversible causes Thus, shorter duration, severe dementia, focal neurological signs, and a vegetarian diet were significantly associated with the development of B12 deficiency.Methods: Based on exclusion and inclusion criteria 100 patients were included in this study, a detailed history of the patient were taken with respect to duration of dementia and its symptoms, type and treatment. Study in terms of the correlation of the clinical features with investigations and diet. Estimation of the prevalence of dementia with reference to B12 deficiency. Mean MMSE analysis, assessment of the improvement in MMSE after treatment with B12 injections after a6-8 wks period.Results: In this study most of our patients were in the 60-69 age groups across all causes of dementia, 22out of 26, B12 deficient patients were vegetarians. This value was in keeping with the known fact that a vegetarian diet predisposes a person to develop B12 deficiency. The association between B12 deficiency, high MCV and megaloblastic blood picture in peripheral blood smear was significant. The MMSE scores were significantly lower 13.42 in patients with B12 deficiency as compared to those with Alzheimer's 14.3 means and those with multi-infarct state 17.3 means.Conclusions: The duration of the presentation in B12 deficiency was10-12months averagely. There was a significant improvement in MMSE after treatment in pureB12 deficient patients (by 9 points) if they presented within one year of symptoms. Except for myelopathy, there was an improvement in other neurological symptoms and signs. Early diagnosis and proper treatment can make improvements in a patient's memory and quality of life.en_US
dc.identifier.affiliationsDepartment of General Medicine, Konaseema Institute of Medical Sciences, Amalapuram, Andhra Pradesh, Indiaen_US
dc.identifier.citationReddy Patirla Devendra, Seela Pranavendra Nath, Maske Pravin Gulab Rao. Study of the prevalence of isolated vitamin B12 deficiency related dementia in patients presenting to a tertiary care hospital. International Journal of Advances in Medicine. 2020 Apr; 7(4): 694-700en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194664
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20201124en_US
dc.subjectDementiaen_US
dc.subjectDieten_US
dc.subjectMean corpuscular volumeen_US
dc.subjectMini-Mental State Exam scoreen_US
dc.subjectVitamin B12 deficiencyen_US
dc.titleStudy of the prevalence of isolated vitamin B12 deficiency related dementia in patients presenting to a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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