Once versus twice daily dose of gentamicin therapy in Thai neonates.

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dc.contributor.authorKosalaraksa, Popeen_US
dc.contributor.authorJanthep, Pakamasen_US
dc.contributor.authorJirapradittha, Junyaen_US
dc.contributor.authorTaksaphan, Sukanyaen_US
dc.contributor.authorKiatchoosakun, Pakaphanen_US
dc.date.accessioned2009-05-27T18:03:39Z
dc.date.available2009-05-27T18:03:39Z
dc.date.issued2004-04-26en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To compare the peak and trough gentamicin concentrations in neonates after a once (ODD) vs. twice daily dosing (TDD) to establish the appropriate dosage for Thai neonates. MATERIAL AND METHOD: Neonates of gestational age > or = 34 weeks, or body weight > or = 2000 g, suspected of having bacterial infection were randomized to receive gentamicin intravenously, either 5 mg/kg every 24 hours or 2.5 mg/kg every 12 hours. The peak and trough serum gentamicin levels (SGLs) were measured. Serum creatinine cued nephrotoxicity. RESULTS: Neonates were evaluated and baseline characteristics between the groups were compared. The ODD and TDD group had a mean gentamicin peak and trough concentration of 10.1 +/- 3.0 vs. 7.8 +/- 2.0 microg/ml (p < 0.05) and 1.6 +/- 1.1 vs. 2.6 +/- 1.2 microg/ml (p < 0.05), respectively. The peak SGL of > or = 4 microg/ml was achieved in 100% vs. 96% of the ODD vs. TDD group, respectively. SGL troughs > or = 2 microg/ml were detected less often in the ODD group (22% vs. 68%, p < 0.05). Abnormal change in serum creatinine was not observed in either group. CONCLUSION: A once daily dose of gentamicin 5 mg/kg achieved a significantly higher peak SGL and safer trough than a twice-daily dose of 2.5 mg/kg albeit about a quarter of the ODD group had high troughs. A single daily dose of gentamicin 3.5-4 mg/kg/d in Thai neonates should be tested.en_US
dc.description.affiliationDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand. pkosalaraksa@yahoo.comen_US
dc.identifier.citationKosalaraksa P, Janthep P, Jirapradittha J, Taksaphan S, Kiatchoosakun P. Once versus twice daily dose of gentamicin therapy in Thai neonates. Journal of the Medical Association of Thailand. 2004 Apr; 87(4): 372-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38373
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAnti-Bacterial Agents --administration & dosageen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshGentamicins --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshSepsis --drug therapyen_US
dc.titleOnce versus twice daily dose of gentamicin therapy in Thai neonates.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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