Susceptibility testing for aztreonam plus ceftazidime/avibactam combination: A general guidance for clinical microbiology laboratories in India
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Date
2022-03
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Association of Medical Microbiologists
Abstract
Metallo beta-lactamases-producing Gram-negative infection is often challenging and there is no defined treatment option. In recent years, the combination of aztreonam with ceftazidime-avibactam has gained much clinical attention mainly for MBL-producing Enterobacterales, while MBL-producing P. aeruginosa and A. baumannii are likely to be resistant. A consensus susceptibility testing method for this triple combination has yet to be recommended. Various methods such as broth disk elution, disk stacking, gradient strip stacking, and strip crossing have been proposed for testing this combination. Among them, broth disk elution and strip based testing methods showed good correlation with the broth micro-dilution method.
Description
Keywords
MBL, Ceftazidime-avibactam, Aztreonam, NDM, OXA-48 like
Citation
Bakthavatchalam Yamuna Devi, Walia Kamini, Veeraraghavan Balaji. Susceptibility testing for aztreonam plus ceftazidime/avibactam combination: A general guidance for clinical microbiology laboratories in India. Indian Journal of Medical Microbiology. 2022 Mar; 40(1): 3-6