Structure-activity relationships of dengue antiviral polycyclic quinones.

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dc.contributor.authorLaurent, Dominiqueen_US
dc.contributor.authorBaumann, Francineen_US
dc.contributor.authorBenoit, Anne Gaelleen_US
dc.contributor.authorMortelecqe, Alainen_US
dc.contributor.authorNitatpattana, Narongen_US
dc.contributor.authorDesvignes, Isabelleen_US
dc.contributor.authorDebitus, Cécileen_US
dc.contributor.authorLaille, Manolaen_US
dc.contributor.authorGonzalez, Jean-Paulen_US
dc.contributor.authorChungue, Elianeen_US
dc.date.accessioned2009-05-27T15:14:35Z
dc.date.available2009-05-27T15:14:35Z
dc.date.issued2005-07-22en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.en_US
dc.description.affiliationLaboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR152 IRD - Université Paul Sabatier, Centre IRD, Nouméa, Nouvelle-Calédonie, France.en_US
dc.identifier.citationLaurent D, Baumann F, Benoit AG, Mortelecqe A, Nitatpattana N, Desvignes I, Debitus C, Laille M, Gonzalez JP, Chungue E. Structure-activity relationships of dengue antiviral polycyclic quinones. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Jul; 36(4): 901-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32284
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2005_36_4/14-3516.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDengue Virusen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshPolycyclic Hydrocarbons, Aromaticen_US
dc.subject.meshQuinonesen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.titleStructure-activity relationships of dengue antiviral polycyclic quinones.en_US
dc.typeJournal Articleen_US
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