Acute changes in left atrial appendage function with premature ventricular complexes

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dc.contributor.authorSukumaran, Suresh Kumaren_US
dc.contributor.authorBhargav, Anishen_US
dc.contributor.authorBalaguru, Sridharen_US
dc.contributor.authorAnantharaj, Avinashen_US
dc.contributor.authorSatheesh, Santhoshen_US
dc.contributor.authorSelvaraj, Raja J.en_US
dc.date.accessioned2025-08-13T11:15:20Z
dc.date.available2025-08-13T11:15:20Z
dc.date.issued2025-06
dc.description.abstractObjectives: Left atrial appendage (LAA) dysfunction is a risk factor for stroke. Evidence shows that frequent premature ventricular complexes (PVCs) are associated with embolic stroke. Whether left atrial dysfunction is the bridging link between frequent premature ventricular complexes and stroke is unknown. Materials and methods: Patients with a structurally normal heart undergoing elective electrophysiology study were included. Transoesophageal echo was used to measure LAA flow velocities. To simulate PVCs in bigeminal rhythm, single paced beats were delivered from the right ventricle with a coupling interval of QT + 10 % RR interval after each sinus beat. LAA flow doppler velocities were acquired at baseline, after 5 min of pacing and again 5 min after cessation of pacing. Results: Ten patients were included in the study. Late diastolic emptying velocity decreased significantly after 5 min of PVCs (55.68 ± 16.33 cm/s, p = 0.01) compared to baseline (68.01 ± 10.34 cm/s). This almost returned to baseline after a rest period of 5 min (63.13 ± 16.16 cm/s, p = 0.277). The left atrial appendage filling velocity exhibited a statistically non-significant trend toward a decrease after 5 min of PVCs (45.70 ± 10.85 cm/s, p = 0.129), compared to the baseline value of 51.31 ± 14.11 cm/s. Conclusions: Premature ventricular complexes in bigeminal pattern for 5 min resulted in an acute decrease in the late diastolic emptying velocity. This is a possible mechanism for the increased risk of strokes in patients with frequent PVCs.en_US
dc.identifier.affiliationsDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Indiaen_US
dc.identifier.citationSukumaran Suresh Kumar, Bhargav Anish, Balaguru Sridhar, Anantharaj Avinash, Satheesh Santhosh, Selvaraj Raja J.. Acute changes in left atrial appendage function with premature ventricular complexes. Indian Heart Journal. 2025 Jun; 77(3): 159-163en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253332
dc.languageenen_US
dc.publisherElsevieren_US
dc.relation.issuenumber3en_US
dc.relation.volume77en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2025.05.001en_US
dc.titleAcute changes in left atrial appendage function with premature ventricular complexesen_US
dc.typeJournal Articleen_US
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