In situ characterization of cells in the dermal infiltrates of lepromin reaction using monoclonal antibodies.

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dc.contributor.authorNarayanan, R Ben_US
dc.contributor.authorRamu, Gen_US
dc.contributor.authorMalaviya, G Nen_US
dc.contributor.authorSengupta, Uen_US
dc.contributor.authorDesikan, K Ven_US
dc.date.accessioned1985-04-01en_US
dc.date.accessioned2009-05-28T10:09:51Z
dc.date.available1985-04-01en_US
dc.date.available2009-05-28T10:09:51Z
dc.date.issued1985-04-01en_US
dc.description.abstractA study was made on the in situ characteristics of dermal infiltrates in the early and late lepromin reaction with monoclonal antibodies defining T cell subsets, Langerhan cells and Ia like antigens. The early reaction (24 hrs) was elicited either with standard Dharmendra lepromin or leprosin-A and the late reaction (3-4 weeks) was elicited with standard Dharmendra lepromin. In all, 15 biopsies were studied. Most lymphocytes in the infiltrates of both the lepromin and leprosin reactions were positive for OKT 11, Leu 3a, OKT 8 and Ia like antigens indicating thereby the presence of activated T cells. A high proportion of OKT6 + cells were also noticed in the infiltrates of these reactions. In the late reaction, the lymphocytes in the granulomas were predominantly activated T lymphocytes expressing OKT 11, Leu 3a, OKT 8 and Ia like antigens. Leu 3a + cells were scattered diffusely amidst the epithelioid cells. In contrast, OKT 8 + cells were present mainly in the peripheral region of the granuloma. A small proportion of OKT6 + cells were also seen in these granulomas. Ia like antigens and T6 antigens were not discernible on the epithelioid cells. No difference in the number of OKT6 + epidermal langerhan cells was observed in the various types of reactions.en_US
dc.identifier.citationNarayanan RB, Ramu G, Malaviya GN, Sengupta U, Desikan KV. In situ characterization of cells in the dermal infiltrates of lepromin reaction using monoclonal antibodies. Indian Journal of Leprosy. 1985 Apr-Jun; 57(2): 265-72en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/54940
dc.language.isoengen_US
dc.subject.meshAntibodies, Monoclonal --diagnostic useen_US
dc.subject.meshAntigens, Bacterial --immunologyen_US
dc.subject.meshGranuloma --immunologyen_US
dc.subject.meshHistocompatibility Antigens Class II --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshLangerhans Cells --immunologyen_US
dc.subject.meshLepromin --immunologyen_US
dc.subject.meshLeprosy --immunologyen_US
dc.subject.meshLymphocytes --pathologyen_US
dc.subject.meshSkin --immunologyen_US
dc.titleIn situ characterization of cells in the dermal infiltrates of lepromin reaction using monoclonal antibodies.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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