Evaluation of prochlorperazine buccal tablets (Bukatel) and metoclopramide oral tablets in the treatment of acute emesis.

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dc.contributor.authorSingh, Sen_US
dc.contributor.authorSharma, D Ren_US
dc.contributor.authorChaudhary, Aen_US
dc.date.accessioned1999-08-22en_US
dc.date.accessioned2009-05-31T15:22:31Z
dc.date.available1999-08-22en_US
dc.date.available2009-05-31T15:22:31Z
dc.date.issued1999-08-22en_US
dc.description.abstractThe dizziness associated with vertiginous disorders is often accompanied with nausea and/or vomiting. Antiemetic effect of prochlorperazine (PCZ) is diminished by its low bioavailability owing to a significant gastric and hepatic first pass effect. This effect could be further diminished by likelihood of regurgitation of nauseating patients further limiting the therapeutic effect of oral PCZ. A buccal preparation achieves higher plasma concentrations through direct systemic absorption. In this study buccal prochlorperazine (Bukatel) was compared for its efficacy and tolerability with commonly used metoclopramide. Bukatel was well tolerated and well rated by both patients and investigators with no adverse effects on buccal mucosa and causing less drowsiness and sedation. Results indicate that Bukatel is safe and effective for the treatment of nausea and/or vomiting in patients suffering from vertiginous disorders and could be safely and strongly recommended as an alternative to less bioavailable and indiscriminately used oral metoclopramide tablets.en_US
dc.description.affiliationUniversity of South Australia, Adelaide.en_US
dc.identifier.citationSingh S, Sharma DR, Chaudhary A. Evaluation of prochlorperazine buccal tablets (Bukatel) and metoclopramide oral tablets in the treatment of acute emesis. Journal of the Indian Medical Association. 1999 Aug; 97(8): 346-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/103452
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAdministration, Buccalen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntiemetics --administration & dosageen_US
dc.subject.meshCholecystectomyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetoclopramide --administration & dosageen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPostoperative Nausea and Vomiting --drug therapyen_US
dc.subject.meshProchlorperazine --administration & dosageen_US
dc.subject.meshQuality of Lifeen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRetreatmenten_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEvaluation of prochlorperazine buccal tablets (Bukatel) and metoclopramide oral tablets in the treatment of acute emesis.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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