Oral etoricoxib for pain relief during fractional curettage: a randomized controlled trial.

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dc.contributor.authorPhittayawechwiwat, Wilaipornen_US
dc.contributor.authorThanantaseth, Chalermsrien_US
dc.contributor.authorAyudhya, Nathpong Israngura Naen_US
dc.contributor.authorO-Prasertsawat, Prataken_US
dc.contributor.authorKongprasert, Jitladaen_US
dc.date.accessioned2009-05-27T21:54:54Z
dc.date.available2009-05-27T21:54:54Z
dc.date.issued2007-06-13en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To compare the efficacy of oral etoricoxib and placebo combined with paracervical block for pain relief during fractional curettage MATERIAL AND METHOD: A double-blind, randomized controlled trial that included 220 women who underwent fractional curettage and received paracervical block for pain relief was done at Ramathibodi Hospital between September 2005 and June 2006. One hundred and ten women were randomly allocated to the etoricoxib group (90 mg, tablet) and 110 to the placebo group. The main outcome was the patient's assessment of intensity of pain measured by verbal rating scales after speculum insertion, during fractional curettage, immediately after curettage, and 30 minutes after curettage. RESULTS: Demographic data including age, previous vaginal deliveries, and history of curettage were not significantly different between etoricoxib group and placebo group. Most common indication for fractional curettage was menometrorrhagia in both groups. Pain score in etoricoxib group was significant lower during fractional curettage (5 vs. 6, p = 0.04), immediately after curettage (2 vs. 3, p = 0. 009), and 30 minutes after curettage (0 vs. 1, p = 0.003). Comparing the number of patients with mild pain (score 0-3), there were significant higher number of mild pain patient at the time during curettage (39 vs. 20 cases), immediate after curettage (78 vs. 60 cases), and 30 minutes after curettage (107 vs. 100 cases) in etoricoxib group. CONCLUSION: Combination of etoricoxib with paracervical block for reduction of pain during fractional curettage had statistically significant lower pain scale when compared with placebo with paracervical block. However the difference was small and may have questionable clinical significance.en_US
dc.description.affiliationDepartment of Obstetrics and Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama IV Rd, Rachatavee, Bangkok 10400, Thailand. taew-p@hotmail.comen_US
dc.identifier.citationPhittayawechwiwat W, Thanantaseth C, Ayudhya NI, O-Prasertsawat P, Kongprasert J. Oral etoricoxib for pain relief during fractional curettage: a randomized controlled trial. Journal of the Medical Association of Thailand. 2007 Jun; 90(6): 1053-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45624
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnesthesia, Obstetrical --methodsen_US
dc.subject.meshCyclooxygenase 2 Inhibitors --administration & dosageen_US
dc.subject.meshDilatation and Curettage --adverse effectsen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPain Measurementen_US
dc.subject.meshPain, Postoperative --drug therapyen_US
dc.subject.meshPerioperative Careen_US
dc.subject.meshPlacebosen_US
dc.subject.meshPyridines --administration & dosageen_US
dc.subject.meshSulfones --administration & dosageen_US
dc.titleOral etoricoxib for pain relief during fractional curettage: a randomized controlled trial.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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