Focal segmental glomerulosclerosis associated with maternally inherited diabetes and deafness: Clinical pathological analysis.
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Date
2013-07
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Abstract
Maternally inherited diabetes and deafness (MIDD), which is caused by an
A to G substitution at position 3243 (m.3243A>G) in the transfer ribonucleic
acid leucine gene, is characterized by diabetes and hearing loss. Patients
with MIDD frequently have renal disease, which may precede the diagnosis of
either diabetes or deafness or may be the sole manifestation of the m.3243A>G
mutation. Recently, progressive renal failure was reported in adults, and a number
of childhood cases of focal segmental glomerulosclerosis (FSGS) of MIDD have
been reported. However, little is known about the glomerular lesions in FSGS
in MIDD. In the present study, we reported two cases of FSGS associated with
MIDD and studied the clinical features of the proband and her mother.
Description
Keywords
Clinical pathology, focal segmental glomerulosclerosis, maternally inherited diabetes and deafness
Citation
Cao Xue Ying, Wei Ri Bao, Wang Yuan Da, Zhang Xue Guang, Tang Li, Chen Xiang Mei. Focal segmental glomerulosclerosis associated with maternally inherited diabetes and deafness: Clinical pathological analysis. Indian Journal of Pathology & Microbiology. 2013 Jul-Sept 56 (3): 277-275.