Collagenase-IV in human trophoblast invasion and differentiation.

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dc.contributor.authorSanyal, Men_US
dc.contributor.authorDas, Cen_US
dc.date.accessioned1997-02-01en_US
dc.date.accessioned2009-05-27T09:49:35Z
dc.date.available1997-02-01en_US
dc.date.available2009-05-27T09:49:35Z
dc.date.issued1997-02-01en_US
dc.description.abstractTrophoblast cells are unique with respect to their functions and responsibilities. These cells demonstrate three sequential phenotypes, proliferation and invasion into the endometrium, differentiation to form syncytia and endocrine secretions. Equipped with these properties placental trophoblasts are endowed with a variety of functions, like implantation of the blastocyst to the endometrium, providing nutrition to the developing embryo and also transmitting extraordinary array of signals for the embryonic development. Experimental evidences and logical extrapolation suggest that these functions are precisely controlled by growth factors, cytokines and hormones produced either by the trophoblast themselves or by the utero-placental unit. Any error in this control mechanism has extremely adverse consequences. The cells also synthesize a large number of enzymes, amongst which collagenase type IV secretion is involved in digestion of underlying basement membrane necessary for the process of invasion. Our results implicate the enzyme in the functional differentiation of the trophoblast as well. Inhibitors to this enzyme inhibit trophoblast differentiation as monitored by secretion of hCG and progesterone, the two markers of trophoblastic differentiation. In contrast, BeWo cells, a choriocarcinoma cell line which does not differentiate spontaneously, undergo increased proliferation when challenged with EGF. The results indicate the possibility of invasive and differentiative phenotypes to be coupled. Exact molecular involvements in this coupling process are looked into.en_US
dc.description.affiliationDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.en_US
dc.identifier.citationSanyal M, Das C. Collagenase-IV in human trophoblast invasion and differentiation. Indian Journal of Biochemistry & Biophysics. 1997 Feb-Apr; 34(1-2): 220-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28675
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Division --drug effectsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshChorionic Gonadotropin --secretionen_US
dc.subject.meshCollagenases --antagonists & inhibitorsen_US
dc.subject.meshEnzyme Inhibitors --pharmacologyen_US
dc.subject.meshEpidermal Growth Factor --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMatrix Metalloproteinase 9en_US
dc.subject.meshPhenanthrolines --pharmacologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProgesterone --secretionen_US
dc.subject.meshTrophoblasts --cytologyen_US
dc.titleCollagenase-IV in human trophoblast invasion and differentiation.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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