Detection of high-level aminoglycoside resistance by disc diffusion and e-test amongst the enterococcus species isolated from various clinical samples in a tertiary care hospital

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dc.contributor.authorPaul, Manishaen_US
dc.contributor.authorNirwan, Prem Singhen_US
dc.contributor.authorSrivastava, Preetien_US
dc.date.accessioned2020-11-18T09:59:35Z
dc.date.available2020-11-18T09:59:35Z
dc.date.issued2019-09
dc.description.abstractBackground: The emergence of Enterococcus species in causing nosocomial infections poses a therapeutic challenge to clinicians. Enterococci are intrinsically resistance to multiple antibiotics. Acquired resistance to commonly used antibiotics like Ampicillin, Vancomycin and Aminoglycosides have made the situation worse and difficult to treat serious Enterococcal infections. The present study aimed at detection of high-level aminoglycoside resistance by disc diffusion and E-test amongst the Enterococcus species isolated from various clinical samples in a tertiary care hospital.Methods: A total of 102 Enterococcus species isolated from various clinical samples and antimicrobial susceptibility was performed by Kirby Bauer disc diffusion method as per CLSI guidelines. E-test was done for all high level aminoglycoside resistance Enterococcus species isolated by disc diffusion test.Results: Among 102 isolates, 81 were E. faecalis, 18 were E. faecium and 3 were another Enterococcus. Their antimicrobial susceptibility pattern shows all isolates were sensitive to vancomycin, linezolid and teicoplanin with HLGR, HLSR detected in 40 and 38 isolates of E. faecalis, 17  and 13 isolates of E. faecium respectively by disc diffusion whereas by E-test it was detected in 44 and 40 in E. faecalis and 17 and 14 in E. faecium respectively. E. faecium is found to be more resistance to high level aminoglycoside than E. faecalis.Conclusions: Authors hereby conclude that Enterococci being the common cause of hospital acquired infections with their increasing resistance to multiple drugs and acquisition of HLAR; it must be routinely screened for various drugs to prevent drug resistance in hospital settings for serious Enterococcal infections.en_US
dc.identifier.affiliationsDepartment of Microbiology, National institute of Medical Science and Research, Jaipur, Rajasthan, Indiaen_US
dc.identifier.citationPaul Manisha, Nirwan Prem Singh, Srivastava Preeti. Detection of high-level aminoglycoside resistance by disc diffusion and e-test amongst the enterococcus species isolated from various clinical samples in a tertiary care hospital. International Journal of Research in Medical Sciences. 2019 Sep; 7(9): 3527-3531en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211731
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20193941en_US
dc.subjectHigh level aminoglycoside resistant ,High level gentamicin resistanten_US
dc.subjectHigh level streptomycin resistanten_US
dc.titleDetection of high-level aminoglycoside resistance by disc diffusion and e-test amongst the enterococcus species isolated from various clinical samples in a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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