Effectiveness of a 12-week physical exercise programme on blood pressure in adults with true resistant hypertension and high risk of obstructive sleep apnoea: a study protocol for a pre-post test non randomised clinical trial

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dc.contributor.authorSuranga, Dassanayakeen_US
dc.contributor.authorGerard, Wilkinsen_US
dc.contributor.authorGisela, Soleen_US
dc.contributor.authorMargot, Skinneren_US
dc.date.accessioned2020-05-06T08:34:23Z
dc.date.available2020-05-06T08:34:23Z
dc.date.issued2020-04
dc.description.abstractBackground:Resistant hypertension, a special phenotype of hypertension, is associated with increased cardiovascular risk. Exercise and physical activity are recommended as non-pharmacological interventions to manage blood pressure in hypertension. Little is known about the effectiveness of exercise in resistant hypertension. A bidirectional relationship has been identified between resistant hypertension and obstructive sleep apnoea but the literature pertaining to the benefit of exercise for populations with both conditions, is minimal. This study aims to identify the effectiveness of exercise in reducing blood pressure in a cohort of adults with resistant hypertension and high risk of obstructive sleep apnoea.Methods:Dunedin based adults with resistant hypertension and high risk of obstructive sleep apnoea will be recruited from the community and health centres to participate in the study. Consenting volunteers (no. of fourteen) will participate in a 12-week exercise programme including aerobic and strength training. The primary outcome measure will be 24h ambulatory blood pressure while the secondary outcomes will be anthropometrics, activity parameters, sleep parameters, cardiac structure and function, and quality of life. The measurements at the end ofthe 12-week exercise programme will be compared with baseline to determine the effectiveness of exercise in reducing blood pressure in the cohort with resistant hypertension and risk of obstructive sleep apnoea. Conclusions: Exercise and physical activity are recommended to manage hypertension. Therefore, it is anticipated that the exercise programme will have a positive effect on the blood pressure of the participants. The findings have potential to change the direction of research in the area by fillingthe knowledge gaps.Trial Registration:The Ministry of Health, New Zealand (Ethics Ref: 18/CEN/257), Trial registry: ACTRN12618001881224p).en_US
dc.identifier.affiliationsCentre for Health, Activity and Rehabilitation Research, School of Physiotherapy, University of Otago, New Zealanden_US
dc.identifier.affiliationsDepartment of Medicine, Dunedin School of Medicine, University of Otago, New Zealanden_US
dc.identifier.citationSuranga Dassanayake, Gerard Wilkins, Gisela Sole, Margot Skinner . Effectiveness of a 12-week physical exercise programme on blood pressure in adults with true resistant hypertension and high risk of obstructive sleep apnoea: a study protocol for a pre-post test non randomised clinical trial. International Journal of Clinical Trials. 2020 Apr; 7(2): 112-122en_US
dc.identifier.issn2349-3240
dc.identifier.issn2349-3259
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200954
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3259.ijct20201717en_US
dc.subjectResistant hypertensionen_US
dc.subjectObstructive sleep apnoeaen_US
dc.subjectExerciseen_US
dc.subjectStudy protocolen_US
dc.subjectNon-randomised trialen_US
dc.titleEffectiveness of a 12-week physical exercise programme on blood pressure in adults with true resistant hypertension and high risk of obstructive sleep apnoea: a study protocol for a pre-post test non randomised clinical trialen_US
dc.typeJournal Articleen_US
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