Salivary transforming growth factor beta in oral submucous fibrosis: A diagnostic and predictive marker

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dc.contributor.authorRai, Arpitaen_US
dc.contributor.authorParveen, Shamaen_US
dc.contributor.authorShree, Priyaen_US
dc.contributor.authorAhmed, Tanveeren_US
dc.contributor.authorAli, Sheren_US
dc.contributor.authorKaur, Mandeepen_US
dc.contributor.authorSircar, Keyaen_US
dc.contributor.authorSybil, Deboraen_US
dc.contributor.authorChandra, Akhileshen_US
dc.date.accessioned2024-11-30T11:56:01Z
dc.date.available2024-11-30T11:56:01Z
dc.date.issued2024-01
dc.description.abstractContext: Growth factors and cytokines like transforming growth factor beta (TGF?b) play a key role in the pathogenesis of oral submucous fibrosis. Aims: To elucidate the role of Salivary TGF?b isoforms as a predictive and diagnostic marker for oral submucous fibrosis. Settings and Design: A total of 30 OSMF and 10 control patients were included in this study, and their clinic?epidemiological data was recorded. Methodology: The expression of TGF?b genes—TGF?b1, TGF?b2, TGF?b3—was studied by a real?time polymerase chain reaction in tissue and saliva. Patients were given medicinal intervention for 12 weeks along with jaw?opening exercises. Expression of salivary TGF?b genes was studied at 12 weeks. Statistical Analysis Used: SPSS software version 20. Result: Expression of salivary TGF beta isoforms in OSMF was more than in the control group. There was an increase in salivary TGF?b1, b2, b3 expressions with increasing clinical grades of OSMF and advancing the stage of the disease. Expression of all the TGF beta isoforms was decreased after treatment with statistically significant results. Statistically significant correlations were found between the mean difference of TGF?b1 and the mean difference between mouth opening and tongue protrusion. Conclusion: Salivary TGF?b isoforms may be used in diagnosis, risk assessment, and screening of the entire population at risk of OSMF after its clinical validation. However, adequate sample size and segmental assessment of the expression of TGF?b isoforms are needed for further evaluation.en_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, Dental College, Rajendra Institute of Medical Sciences, Bariatu, Jharkhand, Indiaen_US
dc.identifier.affiliationsCentre for Interdisciplinary Research in Basic Sciences, Jamia Milia Islamia, Okhla, New Delhi, Indiaen_US
dc.identifier.affiliationsSenior Research Fellow, Oral Medicine and Radiology, Dental College, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsMultidisciplinary Centre for Advance Research and Studies, Jamia Milia Islamia, Okhla, New Delhi, Indiaen_US
dc.identifier.affiliationsVC Office, Era University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsOral Medicine and Radiology, Faculty of Dentistry, Jamia Milia Islamia, Okhla, New Delhi, Indiaen_US
dc.identifier.affiliationsOral Pathology and Microbiology, Faculty of Dentistry, Jamia Milia Islamia, Okhla, New Delhi, Indiaen_US
dc.identifier.affiliationsOral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Milia Islamia, Okhla, New Delhi, Indiaen_US
dc.identifier.affiliationsOral Pathology and Microbiology, Faculty of Dental Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.citationRai Arpita, Parveen Shama, Shree Priya, Ahmed Tanveer, Ali Sher, Kaur Mandeep, Sircar Keya, Sybil Debora, Chandra Akhilesh. Salivary transforming growth factor beta in oral submucous fibrosis: A diagnostic and predictive marker. Journal of Cancer Research and Therapeutics. 2024 Jan; 20(1): 275-280en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/238154
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume20en_US
dc.source.urihttps://doi.org/10.4103/jcrt.jcrt_1929_22en_US
dc.subjectOSMFen_US
dc.subjectPCRen_US
dc.subjectTGF?b isoformsen_US
dc.titleSalivary transforming growth factor beta in oral submucous fibrosis: A diagnostic and predictive markeren_US
dc.typeJournal Articleen_US
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