Medullary thyroid carcinoma with melanin production--a case report.

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dc.contributor.authorSingh, Z Nen_US
dc.contributor.authorRay, Ren_US
dc.contributor.authorKumar, Nen_US
dc.contributor.authorAron, Men_US
dc.contributor.authorGupta, S Den_US
dc.date.accessioned1999-04-20en_US
dc.date.accessioned2009-05-29T13:24:57Z
dc.date.available1999-04-20en_US
dc.date.available2009-05-29T13:24:57Z
dc.date.issued1999-04-20en_US
dc.description.abstractMelanin production in medullary thyroid carcinomas is rare. The present case illustrates melanin and other atypical features of medullary carcinoma of the thyroid in a fifty year old female. The diagnosis was suggested on the cytomorphological features seen on fine needle aspiration cytology smears. On histo-pathological examination the tumor was extensively pigmented with frequent mitosis. Amyloid was conspicuously scarce. Confirmation of diagnosis was done by immunohistochemical positivity for calcitonin and HMB-45 on tissue sections. The case is being presented in view of its rarity and distinct immunoreactivity. Review of literature is done and the implications of such dual positivity in the histogenesis and divergent phenotype of this tumor are discussed.en_US
dc.description.affiliationDepartment of Pathology and Surgery, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSingh ZN, Ray R, Kumar N, Aron M, Gupta SD. Medullary thyroid carcinoma with melanin production--a case report. Indian Journal of Pathology & Microbiology. 1999 Apr; 42(2): 159-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75624
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAntigens, Neoplasmen_US
dc.subject.meshCalcitonin --metabolismen_US
dc.subject.meshCarcinoma, Medullary --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMelanins --biosynthesisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Proteins --metabolismen_US
dc.subject.meshThyroid Neoplasms --metabolismen_US
dc.titleMedullary thyroid carcinoma with melanin production--a case report.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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