Serum neopterin levels in HIV infected patients with & without tuberculosis.

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dc.contributor.authorImmanuel, Chandraen_US
dc.contributor.authorVictor, Lalithaen_US
dc.contributor.authorChelvi, K Silambuen_US
dc.contributor.authorPadmapriyadarsini, Cen_US
dc.contributor.authorRehman, Fathimaen_US
dc.contributor.authorIliayas, Sheiken_US
dc.contributor.authorSwaminathan, Soumyaen_US
dc.date.accessioned2005-04-09en_US
dc.date.accessioned2009-05-27T08:17:12Z
dc.date.available2005-04-09en_US
dc.date.available2009-05-27T08:17:12Z
dc.date.issued2005-04-09en_US
dc.description.abstractBACKGROUND & OBJECTIVE: Three categories of prognostic markers are best documented as having significance in relation to prognosis of HIV infection. These include HIV viral load, CD4 T-cell levels and plasma levels of soluble markers of immune activation. The plasma activation markers, like neopterin, tumor necrosis factor alpha (TNF-alpha), interleukins etc., are products of cytokine activity and represent immunologic changes throughout the body. There is not much information available on serum neopterin estimation in patients infected with both HIV and tuberculosis (TB), though neopterin levels are known to be elevated in pulmonary TB patients. In this study we attempted to correlate neopterin levels with the presence of tuberculosis in HIV infected and uninfected individuals and studied the changes after antituberculosis treatment. METHODS: Serum neopterin concentrations were measured by high performance liquid chromatography (HPLC) in 25 HIV-seropositive (HIV-TB) and 10-seronegative (TB) patients with tuberculosis before, during and at the end of antituberculosis therapy (ATT). S-neo was also measured in 10 HIV-seropositive asymptomatic individuals and 10 healthy controls. The results were correlated with clinical, bacteriological and immunological status. RESULTS: All TB patients regardless of HIV status had elevated s-neo concentrations at diagnosis, which declined gradually during treatment. Patients with HIV/TB with CD4 counts < 200/mm(3) had the highest levels at baseline with a steep fall during treatment. The median level at the end of treatment was significantly higher in HIV/TB than in TB patients, despite clinical improvement and bacteriological clearance of Mycobacterium tuberculosis. HIV infected asymptomatic individuals had neopterin levels that were higher than healthy controls but lower than HIV-TB patients. INTERPRETATION & CONCLUSION: Serum neopterin levels are elevated in HIV-positive patients, with the highest levels in those with tuberculosis and CD4 counts < 200/mm(3). Though the levels decrease with anti tuberculosis therapy, persistently elevated levels indicate progressive HIV disease and a poor prognosis.en_US
dc.description.affiliationTuberculosis Research Centre (ICMR), Mayor V.R. Ramanthan Road, Chetput, Chennai, India.en_US
dc.identifier.citationImmanuel C, Victor L, Chelvi KS, Padmapriyadarsini C, Rehman F, Iliayas S, Swaminathan S. Serum neopterin levels in HIV infected patients with & without tuberculosis. Indian Journal of Medical Research. 2005 Apr; 121(4): 220-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23909
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntitubercular Agents --administration & dosageen_US
dc.subject.meshCD4 Lymphocyte Counten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshHIV Infections --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeopterin --blooden_US
dc.subject.meshTuberculosis --blooden_US
dc.titleSerum neopterin levels in HIV infected patients with & without tuberculosis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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