Acute panmylelosis with myelofibrosis - A rare case report with review of literature

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dc.contributor.authorDahiya, Sen_US
dc.contributor.authorKotwal, Jen_US
dc.contributor.authorLanger, Sen_US
dc.contributor.authorSaraf, Aen_US
dc.contributor.authorPrakhar, Pen_US
dc.contributor.authorGupta, Den_US
dc.contributor.authorGupta, Nen_US
dc.contributor.authorArya, Ven_US
dc.date.accessioned2025-06-19T05:55:11Z
dc.date.available2025-06-19T05:55:11Z
dc.date.issued2025-03
dc.description.abstractAcute panmyelosis with myelofibrosis (APMF) corresponds to <1% cases of acute myeloid leukemia, which could be an underestimation due to missed diagnosis. Due to its rapidly fatal course, it warrants a timely and correct diagnosis. We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation with increased blasts (?20% in the bone marrow or peripheral blood) and accompanying marrow fibrosis. APMF is rare with poor prognosis thus, must be differentiated especially from Acute megakaryoblastic leukemia to arrive at the correct diagnosis which will help reduce/prevent the early mortality by providing timely chemotherapy followed by upfront hemopoietic stem cell transplantation.en_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Sir Ganga Ram Hospital, New Delhi, Delhi, Indiaen_US
dc.identifier.citationDahiya S, Kotwal J, Langer S, Saraf A, Prakhar P, Gupta D, Gupta N, Arya V. Acute panmylelosis with myelofibrosis - A rare case report with review of literature. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 171-175en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249945
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume68en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_391_23en_US
dc.subjectAcute leukemiaen_US
dc.subjectmegakaryoblastic leukemiaen_US
dc.subjectmyelofibrosisen_US
dc.subjectpanmyelosisen_US
dc.titleAcute panmylelosis with myelofibrosis - A rare case report with review of literatureen_US
dc.typeJournal Articleen_US
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