Cytochemical and immunological phenotying of acute nonlymphoblastic leukemia in Thai patients.
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1996-11-01
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Abstract
Using morphology and cytochemical reaction, we could subclassify-according to FAB classification, 51 of our 56 cases of acute nonlymphoblastic leukemia (ANLL) as M1-M5. Five cases were undifferentiated. Using the immunophenotypic method, we could subclassify 51 of these patients as M1-M4. In addition, 3 cases of undifferentiated leukemia by the prior method were each classified as M1, M3, and myelo-megakaryoblastic leukemia. Correlation of ANLL subtype classification according to each method was not good. However, combination of both methods, using immunophenotypic analysis as a supplement would better subclassify the disease. One of the remaining 2 cases of undifferentiated leukemia was also shown to be myelo-megakaryoblastic leukemia by a positive platelet peroxidase reaction by ultrastructural cytochemistry. Thus, combination of these 3 methods could diagnose and subclassify 55 of the 56 cases (98%) of our ANLL patients.
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Chotmaihet Thangphaet.
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Pokatikorn W, Apibal S, Atichartakarn V, Sriurairatana S, Chiewsilp D, Thitikawin P, Timvipark C. Cytochemical and immunological phenotying of acute nonlymphoblastic leukemia in Thai patients. Journal of the Medical Association of Thailand. 1996 Nov; 79(11): 708-14